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 Raman High Throughput Crystallization

 

OMNIC Array Automation Software

OMNIC Array Automation automates data collection and provides sophisticated analytical tools, such as hierarchical cluster analysis, to streamline high throughput crystallization screening tasks that previously required hours of analysis into ones that can be accomplished in a matter of minutes.


Originally designed for the pharmaceutical industry, this breakthrough technology is now seeing acceptance in the agri-chemical industry, where understanding crystallinity is an important factor to research and production. Look for more crystallization success stories in industries ranging from biotech to polymers.

The engine behind Thermo Fisher Scientific's high throughput crystallization analysis is the new OMNIC Array Automation package.

OMNIC Array Automation provides:

  • Automated Data Collection
  • Automated Data Analysis
  • Support for Most Array-based Formats
  • Bidirectional Communications with LIMS
  • Compatibility with most Thermo Fisher Scientific FT-IR and Raman platforms

Product Specification Sheet: Click here (requires registration).

Application Note: Polymorph Characterization using Raman Spectroscopy in High Throughput Crystallization Studies

Polymorphism is the ability of a molecule to exist in more than one stable or meta-stable crystalline state. Distinct crystalline forms exhibit differences in pharmacologically relevant properties in solid dose form drugs. Since polymorphism can have profound effects on the properties, and ultimately the manufacture of a compound under development, it is of critical importance to fully characterize and understand a compound's polymorphic behavior.

Raman spectroscopy, a technique known for its ease of use, minimal sample prep, non-destructive sampling, and the ability to distinguish between crystalline forms, combines with new software to automate crystallization data collection from microtiter well plates, and quickly analyze and present meaningful information. The result is new levels of efficiency in high throughput crystallization (HTC) studies.



See our application note describing this breakthrough in polymorph analysis, salt selection and recrystallization studies. Click here to read.

   

Raman Spectroscopy Products with Array Automation