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 Drug Metabolism Solutions

 

Meet the Challenge of Metabolite Identification with the Best Analytical Instruments Available

Complete solutions for drug metabolism provide confident answers to your tough questions.  Sensitivity, speed, and spectral quality are essential. Thermo Fisher Scientific provides an array of solutions, tools, and resources for performing these complicated analyses.

News

- New Mass Frontier 6.0 Software Released

- Thermo Fisher Scientific Launches LTQ Velos and LTQ Orbitrap Velos

- Thermo Fisher Scientific Launches MetWorks 1.2 for Accurate Metabolite Identification

  

- Get your FREE "Analytical Tools for Metabolism" Resource Kit 

- Watch SMI: Small Molecule Investigation Video

More Information

- Subscribe to Pharma Pipeline e-newsletter

- Sign up to receive Critical Mass, our free mass spectrometry e-newsletter

 

 

Applications

- High Throughput LC-MS/MS Analysis of Metabolic Stability Incubations

- Identification of GSH Conjugates Using Accurate Mass Data and MetWorks Software

- Re-interrogation of Verapamil Metabolites in Bile Using Time-based Data-dependent Mass Lists and a Mass Defect Filter with the LTQ Orbitrap

- Using Multiple Mass Defect Filters and Higher Energy Collisional Dissociation on an LTQ Orbitrap XL for Fast, Sensitive and Accurate Metabolite ID

The Distribution of Metabolites of Di-(2-ethylhexyl) Phthalate on a Whole Rat by Imaging MS Using a MALDI Ion Trap

Experimental Strategies for Determining the Distribution of Erlotinib in Pancreatic Tumors by MALDI Using an LTQ Linear Ion Trap Mass Spectrometer

-Use of FAIMS to Separate Loperamide from PEG Prior to MS Analysis Using an LTQ XL

-Study of Free Radical Fragment Ions Generated from ESI-CID-MS/MS Using LTQ and LTQ Orbitrap Mass Spectrometers

- Analysis of Beer Using a High Speed U-HPLC Coupled to a Linear Ion Trap Hybrid Mass Spectrometer

- Analysis of Parent Drug and Metabolites using FAIMS

- Profiling and Characterization of Polyphenol Polymers from Cinnamon Using the New LCQ Fleet Ion Trap Mass Spectrometer

- High Throughput Approach for Metabolite Profiling and Characterization Using the LXQ Linear Ion Trap MS 

...More

Technical Resources

Video: Accelerate Metabolite ID with Multiple Mass Defect Filtering in MetWorks

- Webinar - Mass Frontier Software Accelerates the Science of Spectral Interpretation

 

- Webinar - MetWorks Software for the Confident Analysis of Metabolism Data

- Applying Multiple Mass Defect Filter (MMDF) to Accurate Mass Data for Fast, Sensitive, and Accurate Identification of Metabolites

- Enhanced Fragmentation of Small Molecules

- Improved Selectivity and Isolation Efficiency Using High Resolution Isolation

 Data Dependent Constant Neutral Loss Scan Function for Identification of Biotransformations

More Product Support Bulletins...

Events

- 2009 Show Schedule

References

- Thermo Scientific References for Drug Metabolism

Products

- LTQ Velos

LTQ Orbitrap Velos

Mass Frontier Software

MALDI Solutions

- LTQ Orbitrap XL Hybrid MS

- LTQ Orbitrap Discovery Hybrid MS

- LTQ XL Linear Ion Trap MS 

- LTQ FT Ultra Hybrid MS

MetWorks

SIEVE Software

Accela High Speed LC

Columns/Consumables

See All MS Solutions