Thermo Fisher Scientific Launches MetWorks™ 1.1.0 Metabolite Identification Software

Thermo Fisher Scientific Inc., the world leader in serving science launched MetWorks™ 1.1.0, an updated version of its proven metabolite identification software. Thermo Scientific Metworks™ 1.1.0 software facilitates automated acquisition, processing and reporting of LC/MSⁿ data in support of biotransformation studies.  MetWorks software is compatible with all Thermo Scientific mass spectrometers capable of performing MS/MS and MSⁿ fragmentation.  In addition, MetWorks allows high resolution accurate mass data from the Thermo Scientific LTQ Orbitrap™ and LTQ FT™ instruments to be fully leveraged.

MetWorks^TM 1.1.0 Software features enhanced tools that facilitate distinguishing xenobiotic components from endogenous biological matrix interferences in LC/MSn chromatograms and spectra.  New features include:

• Automatic generation of a Data-Dependent Parent Mass Table (DDPT)
• Component filtering to exclude duplicates originating from adducts and isotopic contributions
• Flexibility to apply up to six mass defect filters (MDF’s), which are based on high-resolution, exact mass and mass deficiencies of the parent-drug and its putative metabolites
• The structure column in the MetView table can be used to attach a molecular structure drawing (.mol file) to a potential putative candidate

> Download the MetWorks Brochure and the featured application: A High Throughput Approach for Metabolite Profiling and Characterization Using the LXQ Linear Ion Trap Mass Spectrometer

This powerful and flexible data-mining tool for small molecules will be demonstrated in a new, pre-recorded webinar. Entitled "MetWorks 1.1.0 Software for the Confident Analysis of Putative Biotransformation Data", the webinar is available for download from www.thermo.com/mseminar.

See www.thermo.com/metabolism for more drug metabolism solutions.