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Nucleoside and Phosphoramidite Chemistry
We are the leading experts in the manufacture of nucleosides and phosphoramidites. Our phosphoramidites and specialized nucleoside compounds are used in many cutting edge nucleic acid-based diagnostic kits, therapeutics, and enabling research products. Our experience in multiple protection chemistries, synthesis scales, purification strategies and QC methods enables us to respond to new and evolving chemistries.
Our specialties include:
- Modifications of the 2’ position including O-methyl, TBDMSi and fluoro
- Modifications of the 5’ position with acid labile, base labile or photolabile groups
- Base modifications including halogenations, alkylations and others
Nucleic Acid Synthesis and Purification
Thermo Fisher Scientific (Milwaukee) has several decades of experience in the chemical synthesis of nucleic acids and purification of nucleic acids from natural sources. We offer numerous standard oligonucleotide and polynucleotide products such as p(dT) in a variety of lengths and can also provide custom oligonucleotide synthesis services.
Custom syntheses can include:
- incorporation of modified bases
- custom labeling
- 5’ or 3’ modifications
E-mail or call 1-877-886-7629 for more information about these products and services.
Learn more about Custom Molecular Biology
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