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m360 RNAi News for Dharmacon Products Vol. 4 Issue 1

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In this issue

News
The RNAi Global Initiative continues to grow in 2009
At the end of 2008 and early in 2009, Thermo Fisher Scientific Inc., the world leader in serving science, welcomed several new members into the RNAi Global initiative—an alliance of leading international research centers and the Thermo Scientific Dharmacon Products team and R&D teams. The newest member institutions include the Children's Hospital of Eastern Ontario Research Institute and the University of Leiden in the Netherlands...[more]

Product Spotlight
A new siGENOME siRNA library option:
Human and Mouse Transcription factors
Harness the power of RNAi screening with our newest gene collection – human and mouse transcription factors...[more]

SMARTvector™ shRNA Lentiviral Particles – Stable gene silencing revolutionized
With the technological advancements made in developing the SMARTvector platform, you can now effectively deliver stably-expressed silencing sequences into a broad range of cell types...[more]

Making a Difference
The mouse miRIDIAN mimic library uncovers embryonic stem cell specific miRNA involved in cell cycle control
Embryonic stem (ES) cells are derived from the blastocyst stage of embryonic development and are defined by several criteria including the capacity for both self-renewal and pluripotency. Unlike differentiated somatic cells, ES cells do not require any external stimuli to initiate DNA replication...[more]

Current Offers
Accell™ Control Kit–start 2009 with successful RNAi!
It’s not too late to enjoy our offer on the Accell Control kit – everything you need to get started with this breakthrough technology for siRNA delivery into difficult-to-transfect cells – without a transfection reagent.

Species-specific positive controls
Non-targeting negative controls
Your choice of fluorescent control
Resuspension buffer and Accell delivery media

Kit price represents over 30% off the components if purchased separately!
[Order your Accell Control Kit today]

Analyze the full extent of microRNA expression. Start with 50% off a profiling pilot study.*
Thermo Scientific Dharmacon microRNA Expression Profiling Services:

Profiles obtained from total RNA, no need for microRNA enrichment
Unique data normalization strategy using synthetic microRNA reference standard
Seven replicates of every probe, including controls, for greater statistical power
Unmatched service and expertise from the leaders in non-coding RNA biology

*Either 8 or 16 samples, normalized data values provided. Reference code miSMILE. Offer ends March 31, 2009. [Find out more]

Your Opinion Matters
Survey: Gene Expression
Answer a few quick questions and receive a FREE "Life is twisted" T-Shirt!
[Take the survey now]


	Vol. 4 \| Issue 1 \| March '09


	RNAi Learning Center Applications Genome-scale RNAi screens at your benchtop with Decode™ RNAi viral screening libraries The prevalence of genome-scale RNA interference (RNAi) screening increases as our knowledge of genome sequence and annotation increases. These screens can systematically determine the role of each gene in a given phenotype or pathway. Most current strategies for large screens are resource intensive, because each gene is silenced separately. For cost conscious researchers, the Decode™ RNAi viral screening platform from Thermo Scientific Open Biosystems allows for a massively parallel screening approach in a convenient and cost-effective format...[more] Tech.EDU SMARTvector shRNA Lentiviral Platform: Elucidating the Role of Factors Important in Neurite Outgrowth Normal sensory, motor and cognitive functions rely heavily on the ability of neurons to develop the intricate neurite architecture that supports a complex signaling network. Abnormalities of neuronal cell development and differentiation are implicated in many diseases including Alzheimer’s, Parkinson’s and other neurological disorders...[download]