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Q1: I want to do tablet API quantification by FT-NIR but I am not sure which technique is right for me, reflection or transmission?
Thermo Scientific: Depending on the tablet type, either would be suitable. If you are doing uncoated tablets, you can get reliable results using reflection analysis. If the tablets are coated or bi-layered, however, most of the light that comes off the sample is due to the first 300 microns or so of the tablet at the focus which would make reflection inappropriate for this application. In general, transmission analysis is the best experiment for API qualification as it tends to give a better correlation coefficient and lower RMSEC.
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