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Nucleic Acid Synthesis and Labeling

Oligonucleotide Therapeutics

TheraPure® RNA and DNA phosphoramidites meet the purity demanded in oligonucleotide therapeutic manufacturing. Strictly controlled manufacturing processes limit the levels of reactive impurities and reduce the risk of undesirable reactions during synthesis.

Chemical Modifications

Our specialties include:
  • Modifications including O-methyl, TBDMSi, and fluoro
  • Modifications of the 5' position with acid labile, base labile or photolabile groups
  • Base modifications including halogenations and alkylations

Synthesis Supports

We offer several options for solid phase and automated oligonucleotide synthesis

All Biology Needs a Little Chemistry

Thermo Fisher Scientific (Milwaukee) is the global leader in high quality oligonucleotide synthesis and labeling reagents, with expertise in protection chemistries, manufacturing scale up and innovative purification strategies. Our phosphoramidites, labeled amidites and specialized nucleoside compounds are used in many cutting edge nucleic acid diagnostic kits, therapeutics and research products.

E-mail or call 1-877-886-7629 for more information about these products and services.

A New Light on Fluorescent Labels

Compare the performance of DyLight™ Phosphoramidites, Nucleotides and NHS Esters to CyDye™ and Alexa Fluor® dyes.  Our dyes are bright alternatives for labeling during or post oligonucleotide synthesis, without the constraints of licensing or royalites.

CyDye™ is a trademark of GE Healthcare.
Alexa Fluor® is a trademark of Molecular Probes, Inc.

Custom Organic Synthesis

Our experience with synthesis and purification from product concept through manufacturing scale up enables us to respond to our customers' demands for new and evolving chemistries.

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