Molecular determination of stress hormone-mediated drug resistance to Paclitaxel in breast cancer
Melanie Flint1
1University of Pittsburgh
Breast cancer is one of the most frequently diagnosed cancers among women. Although chemotherapy comprises part of successful treatment, as many as 50% of patients do not benefit because their breast cancer cells become resistant to the chemotherapy. Our hypothesis is that drug resistance in breast cancer may arise in part due to stress hormone-induced alterations in cancer cells. To address this hypothesis, breast cancer cells were incubated with paclitaxel in the absence and presence of stress hormones and proteomic profiling using mass spectrometry-based technologies demonstrated that stress hormones significantly alter several proteins within the cell including significant up-regulation of the cell cycle proteins.
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