Our high content reagents for studying transcription factors enable you to study activation through translocation and phosphorylation state readouts. Multiplexed combinations of these assays can be used to create a customized solution for your needs.
Transcription factors can be selectively activated or deactivated by other proteins, often as the final step in signal transduction. Regulation of transcription can occur directly through modification of DNA, post-translation modification of histones, and/or transcription factors. Phosphorylation, acetylation, ubiquitination and other covalent modifications of proteins play an important role in most cellular processes because they can cause rapid changes in the activities of pre-existing proteins. This type of mechanism for regulating protein function is especially crucial in signal transduction pathways and in regulating the cell cycle.
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