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Peer-Reviewed Publications Scientific Review Articles Posters
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Peer Reviewed Publications - 2009
| Author Affiliation | Website | PDF | | Pescini Gobert R, Joubert L, Curchod ML, Salvat C, Foucault I, Jorand-Lebrun C, Lamarine M, Peixoto H, Vignaud C, Frémaux C, Jomotte T, Françon B, Alliod C, Bernasconi L, Abderrahim H, Perrin D, Bombrun A, Zanoguera F, Rommel C, Hooft van Huijsduijnen R. (2009) Convergent Functional Genomics of Oligodendrocyte Differentiation Identifies Multiple Autoinhibitory Signaling Circuits.Mol Cell Biol. 2009 Jan 12. | Merck Serono SA, 1211 Geneva, Switzerland. | Link | | | Mutka SC, Yang WQ, Dong SD, Ward SL, Craig DA, Timmermans PB, Murli S. (2009). Identification of nuclear export inhibitors with potent anticancer activity in vivo. Cancer Res. Jan 15;69(2):510-7 | Kosan Biosciences, Inc, Hayward, California 92121, USA | Link | | | University of British Columbia. | Link | | | Lee S, Lee HG, Kang SH. (2009). Real-time observations of intracellular Mg2+ signaling and waves in a single living ventricular myocyte cell.Anal Chem. Jan 15 | Department of Chemistry and Research Institute of Physics and Chemistry (RINPAC), Chonbuk National University, Jeonju 561-756, South Korea. | Link | | | Chan EY, Longatti A, McKnight NC, Tooze SA.(2009). Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism.Mol Cell Biol. Jan | Secretory Pathways Laboratory, London Research Institute, Cancer Research UK, 44 Lincoln's Inn Fields, London WC2A 3PX, United Kingdom. | Link | | | Wu HL, Li YH, Lin YH, Wang R, Li YB, Tie L, Song QL, Guo DA, Yu HM, Li XJ. (2009). Salvianolic acid B protects human endothelial cells from oxidative stress damage: a possible protective role of glucose-regulated protein 78 induction. Mol Cell Biol. Jan;29(1):157-71. | Department of Pharmacology, School of Basic Medical Sciences, Health Science Center, Peking University, Xueyuan Road, Haidian District, Beijing 100083, PR China. | Link | | | Yutaka Okawa, Teru Hideshima1, Paul Steed, Sonia Vallet, Steven Hall, Ken Huang, John Rice, Amy Barabasz, Brianna Foley, Hiroshi Ikeda, Noopur Raje, Tanyel Kiziltepe, Hiroshi Yasui, Sotaro Enatsu, and Kenneth C. Anderson (2009). SNX-2112, a selective Hsp90 inhibitor, potently inhibits tumor cell growth, angiogenesis, and osteoclastogenesis in multiple myeloma and other hematologic tumors by abrogating signaling via Akt and ERK. Blood, 22 January 2009, Vol. 113, No. 4, pp. 846-855.> | LeBow Institute for Myeloma Therapeutics and Jerome Lipper Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA | Link | | | Tierno MB, Kitchens CA, Petrik B, Graham TH, Wipf P, Xu F, Saunders W, Raccor BS, Balachandran R, Day BW, Stout JR, Walczak CE, Ducruet AP, Reese CE, Lazo JS (2008) Microtubule Binding and Disruption and Induction of Premature Senescence by Disorazole C1. J Pharmacol Exp Ther. Dec 9 | University of Pittsburgh | Link | | | Muniz-Medina V, Jones S, Maglich J, Galardi C, Hollingsworth R, Kazmierski W, Ferris R, Edelstein M, Chiswell K, Kenakin T (2008) The Relative Activity of 'Function Sparing' HIV-1 Entry Inhibitors on Viral Entry and CCR5 Internalization: Is Allosteric Functional Selectivity a Valuable Therapeutic Property? Mol Pharmacol. Dec 8 | GSK | Link | |
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Peer-Reviewed Publications - 2008
| Author Affiliation | Website | PDF | | Levina V, Su Y, Nolen B, Liu X, Gordin Y, Lee M, Lokshin A, Gorelik E (2008) Chemotherapeutic drugs and human tumor cells cytokine network.Int J Cancer.Aug 11 | Department of Medicine, University of Pittsburgh | Link | | | O'Brien C, Cavet G, Pandita A, Hu X, Haydu L, Mohan S, Toy K, Rivers CS, Modrusan Z, Amler LC, Lackner MR (2008) Functional genomics identifies ABCC3 as a mediator of taxane resistance in HER2-amplified breast cancer.Cancer Res. Jul 1;68(13):5380-9 | Departments of Oncology Diagnostics, Bioinformatics, and Molecular Biology, Genentech, Inc., South San Francisco, California | Link | | | Wong HK, Bauer PO, Kurosawa M, Goswami A, Washizu C, Machida Y, Tosaki A, Yamada M, Knöpfel T, Nakamura T, Nukina N (2008) Blocking acid-sensing ion channel 1 alleviates Huntington's disease pathology via an ubiquitin-proteasome system-dependent mechanism | Laboratory for Structural Neuropathology, RIKEN Brain Science Institute, Hirosawa, Wako-shi, Saitama, Japan | Link | | | Trzcinska-Daneluti A, Ly D, Huynh L, Jiang C, Fladd C, Rotin D. (2008) High-content functional screen to identify proteins that correct F508del-CFTR function. Mol Cell Proteomics. Dec 15 | The Hospital for Sick Children, Toronto, Ontario M5G 1L7 | Link | | | Zhang G, Liu X, Farkas AM, Parwani AV, Lathrop KL, Lenzner D, Land SR, Srinivas H (2008) Estrogen Receptor Beta Functions through Non-genomic Mechanisms in Lung Cancer Cells. Mol Endocrinol. Dec 23 | University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA 15213 | Link | | | Law JH, Habibi G, Hu K, Masoudi H, Wang MY, Stratford AL, Park E, Gee JM, Finlay P, Jones HE, Nicholson RI, Carboni J, Gottardis M, Pollak M, Dunn SE (2008) Phosphorylated insulin-like growth factor-i/insulin receptor is present in all breast cancer subtypes and is related to poor survival. | Department of Pediatrics, Laboratory for Oncogenomic Research, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada | Link | | | Huang, Shuguang (2008) Classification of cell subpopulations using multiple cellular parameters from high-content imaging studies. J Biomol Screen. Dec;13(10):941-52 | Department of Biostatistics, Wyeth Pharmaceutical Research, Pearl River, New York. shu444@gmail.com | Link | | | Purpura KA, George SH, Dang SM, Choi K, Nagy A, Zandstra PW (2008) Soluble Flt-1 regulates Flk-1 activation to control hematopoietic and endothelial development in an oxygen-responsive manner. Stem Cells. 2008 Nov;26(11):2832-42 | Department of Chemical Engineering and Applied Chemistry, Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada | Link | | | Ross-Macdonald P, de Silva H, Guo Q, Xiao H, Hung CY, Penhallow B, Markwalder J, He L, Attar RM, Lin TA, Seitz S, Tilford C, Wardwell-Swanson J, Jackson D (2008) Identification of a nonkinase target mediating cytotoxicity of novel kinase inhibitors.Mol Cancer Ther. Nov;7(11):3490-8 | Bristol-Myers Squibb Research and Development, Princeton, NJ | Link | | | Zhang Y, Gavriil M, Lucas J, Mandiyan S, Follettie M, Diesl V, Sum FW, Powell D, Haney S, Abraham R, Arndt K (2008) IkappaBalpha kinase inhibitor IKI-1 conferred tumor necrosis factor alpha sensitivity to pancreatic cancer cells and a xenograft tumor model. Cancer Res. 2008 Nov 15;68(22):9519-24 | Department of Oncology, Wyeth Research, Pearl River, New York, USA | Link | | | He X, Fang L, Wang J, Yi Y, Zhang S, Xie X (2008) Bryostatin-5 blocks stromal cell-derived factor-1 induced chemotaxis via desensitization and down-regulation of cell surface CXCR4 receptors. Cancer Res. Nov 1;68(21):8678-86 | National Center for Drug Screening, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Graduate University of the Chinese Academy of Sciences, Shanghai, China | Link | | | Lee SH, Sterling H, Burlingame A, McCormick F (2008) Tpr directly binds to Mad1 and Mad2 and is important for the Mad1-Mad2-mediated mitotic spindle checkpoint.Genes Dev. Nov 1;22(21):2926-31 | Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California 94115, USA | Link | | | Furukawa Y, Kaneko K, Yamanaka K, O'Halloran TV, Nukina N (2008) Complete loss of post-translational modifications triggers fibrillar aggregation of SOD1 in familial form of ALS. J Biol Chem. Jun 13 | Laboratory for Structural Neuropathology, RIKEN, Brain Science Institute, Wako, Saitama | Link | | | Abraham VC, Towne DL, Waring JF, Warrior U, Burns DJ (2008) Application of a high-content multiparameter cytotoxicity assay to prioritize compounds based on toxicity potential in humans. Jul;13(6):527-37 | Lead Discovery, Abbott Laboratories, Abbott Park, IL | Link | | | Dijkmans TF, van Hooijdonk LW, Schouten TG, Kamphorst JT, Vellinga AC, Meerman JH, Fitzsimons CP, de Kloet ER, Vreugdenhil E (2008) Temporal and functional dynamics of the transcriptome during nerve growth factor-induced differentiation. J Neurochem. Apr 9 | Division of Medical Pharmacology, Leiden/Amsterdam Center for Drug Research and Leiden University Medical Center, The Netherlands | Link | | | Breier JM, Radio NM, Mundy WR, Shafer TJ.(2008) Development of a high-throughput screening assay for chemical effects on proliferation and viability of immortalized human neural progenitor cells. Toxicol Sci. 2008 Sep;105(1):119-33. Jun 11 | The Curriculum in Toxicology, UNC School of Medicine, The University of North Carolina at Chapel Hill | Link | | | Zavareh RB, Lau KS, Hurren R, Datti A, Ashline DJ, Gronda M, Cheung P, Simpson CD, Liu W, Wasylishen AR, Boutros PC, Shi H, Vengopal A, Jurisica I, Penn LZ, Reinhold VN, Ezzat S, Wrana J, Rose DR, Schachter H, Dennis JW, Schimmer AD (2008) Inhibition of the sodium/potassium ATPase impairs N-glycan expression and function. Cancer Res. Aug 15;68(16):6688-97 | Ontario Cancer Institute, Princess Margaret Hospital, Canada | Link | | | Bauwens CL, Peerani R, Niebruegge S, Woodhouse KA, Kumacheva E, Husain M, Zandstra PW (2008) Control of Human Embryonic Stem Cell Colony and Aggregate Size Heterogeneity Influences Differentiation Trajectories.Stem Cells | Department of Chemical Engineering and Applied Chemistry, University of Toronto; Institute of Biomaterials and Biomedical Engineering, University of Toronto. | Link | | | Radio NM, Mundy WR (2008) Developmental neurotoxicity testing in vitro: Models for assessing chemical effects on neurite outgrowth. Neurotoxicology. 361-76. Epub Mar 4 | National Health and Environmental Effects Research Laboratory, U.S. Environmental Protections Agency (USEPA), Research Triangle Park, NC | Link | | | Mundy WR, Robinette B, Radio NM, Freudenrich TM. (2008) Protein biomarkers associated with growth and synaptogenesis in a cell culture model of neuronal development.Toxicology.Jul 30;249(2-3):220-9. | Cellular and Molecular Toxicology Branch, Neurotoxicology Division, U.S. Environmental Protection Agency, Research Triangle Park, NC | Link | | | Alberti Kristin, Davey Ryan E., Kento Onishi, George Sophia, Salchert Katrin, Seib Philipp F., Bornhauser Martin, Pompe Tilo, Nagy Andras, Werner Carsten and Zandstra Peter W. (July 2008) “Functional immobilization of signaling proteins enables control of stem cell fate.” Nature Methods. 5(7): 645-650 | Leibniz Institute of Polymer Research Dresden, Max Bergmann Center of Biomaterials, Dresden, Germany | Link | | | Radio NM, Breier JM, Shafer TJ, Mundy WR (2008) Assessment of chemical effects on neurite outgrowth in PC12 cells using high content screening.Toxicol Sci. Jun 6 | Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protections Agency. | Link | | | Zhou W, Zhu X, Zhu L, Cui YY, Wang H, Qi H, Ren QS, Chen HZ (2008) Neuroprotection of muscarinic receptor agonist pilocarpine against glutamate-induced apoptosis in retinal neurons.Cell Mol Neurobiol. 2008 Feb;28(2):263-75. Jan 3 | Department of Pharmacology, Shanghai Jiao Tong University School of Medicine, Shanghai China | Link | | | Jeffrey KD, Alejandro EU, Luciani DS, Kalynyak TB, Hu X, Li H, Lin Y, Townsend RR, Polonsky KS, Johnson JD. (2008) Carboxypeptidase E mediates palmitate-induced {beta}-cell ER stress and apoptosis. Proc Natl Acad Sci U S A. Jun 11 | Department of Cellular and Physiological Sciences, University of British Columbia | Link | | | Johnson MC, Damon IK, Karem KL. (2008) A rapid, high-throughput vaccinia virus neutralization assay for testing smallpox vaccine efficacy based on detection of green fluorescent protein. J Virol Methods. Jun;150(1-2):14-20. | Division of Viral and Rickettsial Diseases, US Centers for Disease Control and Prevention | Link | | | Barnard R, Barnard A, Salmon G, Liu W, Sreckovic S. (2008) Histamine-induced actin polymerization in human eosinophils: an imaging approach for histamine H4 receptor. Cytometry A. Apr;73(4):299-304 | Biomarkers & Translational Biology, Pfizer | Link | | | Rogers GC, Rusan NM, Peifer M, Rogers SL. (2008) A Multi-Component Assembly Pathway Contributes to the Formation of Acentrosomal Microtubule Arrays in Interphase Drosophila cells. Mol Biol Cell. May 7 | Department of Biology, Lineberger Comprehensive Cancer Center, and Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill | Link | | | Dykens JA, Jamieson JD, Marroquin LD, Nadanaciva S, Xu JJ, Dunn MC, Smith AR, Will Y. (2008) In vitro assessment of mitochondrial dysfunction and cytotoxicity of nefazodone, trazodone, and buspirone. Toxicol Sci. Jun;103(2):335-45 | Drug Safety Research and Development, Pfizer, Inc. | Link | | | Sarker KP, Kataoka H, Chan A, Netherton SJ, Pot I, Huynh MA, Feng X, Bonni A, Riabowol K, Bonni S. (2008) ING2 as a Novel Mediator of Transforming Growth Factor-{beta}-dependent Responses in Epithelial Cells. J Biol Chem. May 9;283(19):13269-79 | Southern Alberta Cancer Research Institute, Departments of Biochemistry & Molecular Biology and Oncology, Faculty of Medicine, University of Calgary | Link | | | Wang JJ, Zhang SX, Mott R, Chen Y, Knapp RR, Cao W, Ma JX. (2008) Anti-inflammatory Effects of Pigment Epithelium-derived Factor in Diabetic Nephropathy. Am J Physiol Renal Physiol. 294. F1166-1173 | Cell biology, Endocrinology, University of Oklahoma | Link | | | Beith Jennifer L., Alejandro Emilyn U. and Johnson James D. (2008) Insulin Stimulates Primary β-Cell Proliferation via Raf-1 Kinase. Endocrinology Vol. 149, No. 5 2251-2260 | University of British Columbia, Vancouver, British Columbia | Link | | | Narahari Janaki , Morgan Aric , Vattem Krishna , Sullivan Yvonne, Hughes Douglas , Hommema Eric , Kilmer Greg and Webb Brian (2008) Analysis of Signaling Pathways using Antibody Microarrays and RNA Interference. The FASEB Journal;22:645.16 | Research & Development, Thermo Fisher Scientific, Rockford, IL | Link | | | Low J, Stancato L, Lee J, Sutherland JJ. (2008) Prioritizing hits from phenotypic high-content screens. Curr Opin Drug Discov Devel. May;11(3):338-45 | Eli Lilly & Co. | Link | | | Williams Gareth , Wood Andrew , Williams Emma-Jane , Gao Ying, Mercado Mary L. , Katz Alan , Joseph-McCarthy Diane , Bates Brian , Ling Huai-Ping , Aulabaugh Ann , Zaccardi Joe , Xie Yuhong , Pangalos Menelas N. , Walsh Frank S. , and Doherty Patrick (2008) Ganglioside inhibition of neurite outgrowth requires Nogo receptor function; identification of interaction sites and development of novel antagonists. J. Biol. Chem, 10.1074/jbc.M802067200 | Wolfson Centre for Age-Related Diseases, Kings College London, London | Link | | | Wei Shao-Yin , Li Min *, Tang Sheng-An , Sun Wan , Xu Bo , Cui Jing-Rong , Lin Wen-Han (2008) Induction of apoptosis accompanying with G1 phase arrest and microtubule disassembly in human hepatoma cells by jaspolide B, a new isomalabaricane-type triterpene. Cancer Letters 262 (2008) 114–122 | State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing, China | Link | | | Loh SH, Francescut L, Lingor P, Bähr M, Nicotera P. (2008) Identification of new kinase clusters required for neurite outgrowth and retraction by a loss-of-function RNA interference screen. Cell Death Differ. Feb;15(2):283-98. | MRC Toxicology Unit, University of Leicester, Leicester, UK | Link | | | Levina V, Marrangoni AM, Demarco R, Gorelik E, Lokshin AE. (2008) Multiple effects of TRAIL in human carcinoma cells: Induction of apoptosis, senescence, proliferation, and cytokine production. Exp Cell Res. Apr 15;314(7):1605-16 | Department of Medicine and University of Pittsburgh Cancer Institute, University of Pittsburgh | Link | | | Basu Partha ,Ghosh Richik N. , Grove Linnette E. , Klei Linda , and Barchowsky Aaron (2008) Angiogenic Potential of 3-Nitro-4-Hydroxy Benzene Arsonic Acid (Roxarsone) Environmental Health Perspectives Volume 116, Number 4, April 2008 | Department of Chemistry and Biochemistry, Duquesne University, Department of Environmental and Occupational Health, University of Pittsburgh, Thermo Fisher Scientific | Link | | | Cummings Jeffrey , Hodgkinson Cassandra , Odedra Rajesh , Sini Patrizia , Heaton Simon P. , Mundt Kirsten E. , Ward Tim H. , Wilkinson Robert W. , Growcott Jim , Hughes Andrew and Dive Caroline (2008) Preclinical evaluation of M30 and M65 ELISAs as biomarkers of drug induced tumor cell death and antitumor activity. Molecular Cancer Therapeutics 7, 455-463, March 1 | Clinical and Experimental Pharmacology, Paterson Institute for Cancer Research, University of Manchester, Cancer and Infection Research Area, AstraZeneca Pharmaceuticals | Link | | | Vogt Andreas , McDonald Peter R. , Tamewitz Aletheia , Sikorski Rachel P. , Wipf Peter , Skoko John J. III and Lazo John S. (2008) A cell-active inhibitor of mitogen-activated protein kinase phosphatases restores paclitaxel-induced apoptosis in dexamethasone-protected cancer cells Molecular Cancer Therapeutics 7, 330-340, February 1 | Departments of Pharmacology and Chemistry, University of Pittsburgh Drug Discovery Institute and Pittsburgh Molecular Libraries Screening Center | Link | | | Raccor Brianne S. , Vogt Andreas , Sikorski Rachel P., Madiraju Charitha , Balachandran Raghavan , Montgomery Kia , Shin Youseung , Fukui Yoshikazu , Jung Won-Hyuk , Curran Dennis P. , and Day Billy W. (2008) Cell-Based and Biochemical Structure-Activity Analyses of Analogs of the Microtubule Stabilizer Dictyostatin. Mol Pharmacol. Mar;73(3):718-26 | Departments of Chemistry, Pharmacology, Drug Discovery Institute, and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh. | Link | | | Trammell Matthew A. , Mahoney Nicole M. , Agard David A. and Vale Ronald D. , (2008) Mob4 plays a role in spindle focusing in Drosophila S2 cells. Journal of Cell Science 121, 1284-1292 | The Howard Hughes Medical Institute and the Department of Biochemistry and Biophysics, University of California | Link | | | Tay Yvonne M.-S. , Tama Wai-Leong , Anga Yen-Sin , Gaughwina Philip M. , Yangb Henry , Wanga Weijia , Liua Rubing , Joshy George, Nga Huck-Hui , Pererad Ranjan J. , Lufkina Thomas , Rigoutsose Isidore, Thomsona Andrew M. ,Lima Bing (2008) MicroRNA-134 Modulates the Differentiation of Mouse Embryonic Stem Cells, Where It Causes Post-Transcriptional Attenuation of Nanog and LRH1. Stem Cells Vol.26 No. 1 January, pp.17-29 | Genome Institute of Singapore, Singapore, Harvard Medical School | Link | |
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Peer-Reviewed Publications - 2007
| Authour Affiliation | Website | PDF | | Benanti JA, Cheung SK, Brady MC, Toczyski DP.(2008). A proteomic screen reveals SCFGrr1 targets that regulate the glycolytic-gluconeogenic switch.Nat Cell Biol. 2007 Oct;9(10):1184-91. | Department of Biochemistry and Biophysics, Cancer Research Institute, University of California, San Francisco | Link | | | Huang X, Li M, Xu B, Zhu X, Deng Z, Lin W. (2007) Proteasome and NF-kappaB inhibiting phaeophytins from the green alga Cladophora fascicularis. Molecules. Mar 21;12(3):582-92. | State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, China. | Link | | | Tao CY, Hoyt J, Feng Y. (2007) A support vector machine classifier for recognizing mitotic subphases using high-content screening data. J Biomol Screen. Jun;12(4):490-6. | Genome and Proteome Sciences Novartis Institutes for Biomedical Research | Link | | | Zhang L, Yu J, Pan H, Hu P, Hao Y, Cai W, Zhu H, Yu AD, Xie X, Ma D, Yuan J. (2007) Small molecule regulators of autophagy identified by an image-based high-throughput screen. Proc Natl Acad Sci U S A. Nov 27;104(48) | Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, China | Link | | | Dürr O, Duval F, Nichols A, Lang P, Brodte A, Heyse S, Besson D. (2007) Robust hit identification by quality assurance and multivariate data analysis of a high-content, cell-based assay. J Biomol Screen. Dec;12(8):1042-9. | Genedata AG | Link | | | Plun-Favreau H, Klupsch K, Moisoi N, Gandhi S, Kjaer S, Frith D, Harvey K, Deas E, Harvey RJ, McDonald N, Wood NW, Martins LM, Downward J. (2007) The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1. Nat Cell Biol. Nov;9(11):1227-9. | Signal Transduction, Cancer Research UK London Research Institute | Link | | | D. Kent Arrell, Nicolas J. Niederländer, Randolph S. Faustino, Atta Behfar, Andre Terzic (2007) Cardioinductive Network Guiding Stem Cell Differentiation Revealed by Proteomic Cartography of Tumor Necrosis Factor -Primed Endodermal Secretome. Stem Cells Vol. 26 No. 2 February, pp. 387 -400 | Marriott Heart Disease Research Program, Division of Cardiovascular Diseases, Departments of Medicine, Molecular Pharmacology and Experimental Therapeutics, and Medical Genetics, Mayo Clinic College of Medicine | Link | | | To K, Y. Zhao, H. Jiang, K. Hu, M. Wang, J. Wu, C. Lee, D. W. Yokom, A. L. Stratford, U. Klinge, P. R. Mertens, C. S. Chen, M. Bally, D. Yapp, and S. E. Dunn. (2007) The Phosphoinositide-Dependent Kinase-1 Inhibitor 2-Amino-N-[4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-acetamide (OSU-03012) Prevents Y-Box Binding Protein-1 from Inducing Epidermal Growth Factor Receptor. Mol. Pharmacol. 72: 641 - 652. | University of British Columbia, RWTH Aachen University, Aachen, Germany and Ohio State University | Link | | | Baniecki ML, Wirth DF, and Clardy J. (2007) High-Throughput Plasmodium falciparum Growth Assay for Malaria Drug Discovery. Antimicrob. Agents Chemother.; 51: 716 - 723. | Harvard Medical School | Link | | | Gupta V,Gylling A, Alonso JL, Sugimori T, Ianakiev P, Xiong JP, and Arnaout MA. (2007) The ß-tail domain (ßTD) regulates physiologic ligand binding to integrin CD11b/CD18. Blood, 109: 3513 - 3520. | Harvard Medical School | Link | | | Wickström M, Johnsen JI, Ponthan F, Segerström L, Sveinbjörnsson B, Lindskog M, Lövborg H, Viktorsson K, Lewensohn R, Kogner P, Larsson R, and Gullbo J. (2007) The novel melphalan prodrug J1 inhibits neuroblastoma growth in vitro and in vivo. Mol. Cancer Ther., 6: 2409 - 2417. | Uppsala University Hospital | Link | | | Doi H, Okamura K, Bauer PO, Furukawa Y, Shimizu H, Kurosawa M, Machida Y, Miyazaki H, Mitsui K, Kuroiwa Y, and Nukina N. (2007) RNA-binding protein TLS is a major nuclear aggregate-interacting protein in Huntingtin exon 1 with expanded polyglutamine-expressing cells. J. Biol. Chem., 10.1074/jbc.M705306200. | RIKEN Brain Science Institute | Link | | | Raccor BS, Vogt A, Sikorski RP, Madiraju C, Balachandran R, Montgomery K, Shin Y, Fukui Y, Jung WH, Curran DP, and Day BW. (2007) Cell-Based and Biochemical Structure-Activity Analyses of Analogues of the Microtubule Stabilizer Dictyostatin. Mol. Pharmacol., 10.1124/mol.107.042598 | University of Pittsburgh | Link | | | Guan Y, Kuo WL, Stilwell JL, Takano H, Lapuk AV, Fridlyand J, Mao JH, Yu M, Miller MA, Santos JL, Kalloger SE, Carlson JW, Ginzinger DG, Celniker SE, Mills GB, Huntsman DG, and Gray W. (2007) Amplification of PVT1 Contributes to the Pathophysiology of Ovarian and Breast Cancer. Clin. Cancer Res., 13: 5745 - 5755. | Lawrence Berkeley National Laboratory | Link | | | Steinberg BE, Scott CC, and Grinstein S. (2007) High-throughput assays of phagocytosis, phagosome maturation, and bacterial invasion. Am J Physiol Cell Physiol, 292: C945 - C952. | The Hospital for Sick Children, Toronto | Link | | | Joslin EJ, Opresko LK, Wells A, H. Wiley HS, and Lauffenburger DA. (2007) EGF-receptor-mediated mammary epithelial cell migration is driven by sustained ERK signaling from autocrine stimulation. J. Cell Sci., 120: 3688 - 3699. | Department of Biological Engineering, MIT | Link | | | Badura L, Swanson T, Adamowicz W, Adams J, Cianfrogna J, Fisher K, Holland J, Kleiman R, Nelson F, Reynolds L, St. Germain K, Schaeffer E, Tate B, and Sprouse J. (2007) An Inhibitor of Casein Kinase I Induces Phase Delays in Circadian Rhythms under Free-Running and Entrained Conditions. J. Pharmacol. Exp. Ther., Aug 2007; 322: 730 - 738. | Pfizer Global Research and Development | Link | | | Tian F, Grimaldo S, Fugita M, Cutts J, Vujanovic NL, and Li LY. (2007) The Endothelial Cell-Produced Antiangiogenic Cytokine Vascular Endothelial Growth Inhibitor Induces Dendritic Cell Maturation. J. Immunol., 179: 3742 - 3751. | University of Pittsburgh Cancer Institute and Department of Pathology | Link | | | Howes AL, Chiang GG, Lang ES, Ho CB, Powis G, Vuori K, and Abraham RT. (2007) The phosphatidylinositol 3-kinase inhibitor, PX-866, is a potent inhibitor of cancer cell motility and growth in three-dimensional cultures. Mol. Cancer Ther., 6: 2505 - 2514. | Burnham Institute for Medical Research | Link | | | Rigamonti D, Bolognini D, Mutti C, Zuccato C, Tartari M, Sola F, Valenza M, Kazantsev AG, and Cattaneo E. (2007) Loss of Huntingtin Function Complemented by Small Molecules Acting as Repressor Element 1/Neuron Restrictive Silencer Element Silencer Modulators. J. Biol. Chem., Aug 2007; 282: 24554 - 24562. | University of Milan | Link | | | Gonzalez-Suarez E, Branstetter D, Armstrong A, Dinh H, Blumberg H, and Dougall WC. (2007) RANK Overexpression in Transgenic Mice with Mouse Mammary Tumor Virus Promoter-Controlled RANK Increases Proliferation and Impairs Alveolar Differentiation in the Mammary Epithelia and Disrupts Lumen Formation in Cultured Epithelial Acini. Mol. Cell. Biol., 27: 1442 - 1454. | Amgen | Link | | | Bednarek R, Boncela J, Smolarczyk K, Cierniewska-Cieslak A, Wyroba E, and Cierniewski CS. (2007) KU80 as a novel receptor for thymosin B4 that mediates its intracellular activity different from G-actin sequestering. J. Biol. Chem., Vol. 283, Issue 3, 1534-1544. | Medical University in Lodz, Poland | Link | | | Young DW, Bender A, Hoyt J, McWhinnie E, Chirn GW, Tao CY, Tallarico JA, Labow M, Jenkins JL, Mitchison TJ, Feng Y. (2007) Integrating high-content screening and ligand-target prediction to identify mechanism of action. Nat Chem Biol. Nat Chem Biol. Jan;4(1):59-68. | Developmental and Molecular Pathways, Novartis Institutes for BioMedical Research, Department of Systems Biology, Harvard Medical School | Link | | Arrell DK, Niederländer NJ, Faustino RS, Behfar A, Terzic A. (2007) Cardioinductive network guiding stem cell differentiation revealed by proteomic cartography of TNF{alpha}-primed enodermal secretome. Stem Cells. Nov 15 Marriott Heart Disease Research Program, Division of Cardiovascular Diseases, Departments of Medicine, Molecular Pharmacology & Experimental Therapeutics, and Medical Genetics, Mayo Clinic College of Medicine, Rochester, Minnesota Link
Tay YM, Tam WL, Ang YS, Gaughwin PM, Yang HH, Wang W, Liu R, George J, Ng HH, Perera RJ, Lufkin T, Rigoutsos I, Thomson AM, Lim B. (2007) MicroRNA-134 Modulates the Differentiation of Mouse Embryonic Stem Cells where it Causes Post-transcriptional Attenuation of Nanog and LRH1. Stem Cells. Oct 18 | Stem Cell and Developmental Biology, Genome Institute of Singapore, Singapore. | Link | | | Lawrence JM, Singhal S, Bhatia B, Keegan DJ, Reh TA, Luthert PJ, Khaw PT, Limb GA. (2007) MIO-M1 cells and similar muller glial cell lines derived from adult human retina exhibit neural stem cell characteristics. Stem Cells. Aug;25(8):2033-43. | Ocular Repair and Regeneration Biology Unit, Department of Cell Biology, Institute of Ophthalmology, London, UK. | Link | | | Peerani R, Rao BM, Bauwens C, Yin T, Wood GA, Nagy A, Kumacheva E, Zandstra PW. (2007) Niche-mediated control of human embryonic stem cell self-renewal and differentiation. EMBO J. Nov 14;26(22):4744-55. | Institute of Biomaterials and Biomedical Engineering, University of Toronto | Link | | | Nabiev I, Mitchell S, Davies A, Williams Y, Kelleher D, Moore R, Gun'ko YK, Byrne S, Rakovich YP, Donegan JF, Sukhanova A, Conroy J, Cottell D, Gaponik N, Rogach A, Volkov Y. (2007) Nonfunctionalized Nanocrystals Can Exploit a Cell's Active Transport Machinery Delivering Them to Specific Nuclear and Cytoplasmic Compartments. Nano Lett. Nov 14;7(11):3452-3461 | Trinity College Dublin, University College Dublin, Technische Universität Dresden, Ludwig-Maximilians-Universität München | Link | | Gasparri F, Ciavolella A, Galvani A.
(2007) Cell-cycle inhibitor profiling by high-content analysis. Adv Exp Med Biol; 604:137-48. | Nerviano Medical Sciences, Milano, Italy. | Link | | | Sartore-Bianchi A, Gasparri F, Galvani A, Nici L, Darnowski JW, Barbone D, Fennell DA, Gaudino G, Porta C, Mutti L. (2007) Bortezomib inhibits nuclear factor-kappaB dependent survival and has potent in vivo activity in mesothelioma. Clin Cancer Res. Oct 1;13(19):5942-51. | Nerviano Medical Sciences, Milano, Italy. | Link | | | Michele Agler*, Margaret Prack, Yingjie Zhu, Janet Kolb, Kimberly Nowak, Rolf Ryseck, Ding Shen, Mary Ellen Cvijic, John Somerville, Steve Nadler, and Taosheng Chen (2007) A High-Content Glucocorticoid Receptor Translocation Assay for Compound Mechanism-of-Action Evaluation. J Biomol Screen. Dec;12(8):1029-41. | Bristol Myers Squibb | Link | | | Wang J, Xie X. (2007) Development of a quantitative, cell-based, high-content screening assay for epidermal growth factor receptor modulators. Acta Pharmacol Sin. Oct;28(10):1698-704. | The National Center for Drug Screening, Shanghai Institute of Materia Medica | Link | | | Emily Walker, Minako Ohishi, Ryan E. Davey, Wen Zhang, Paul A. Cassar, Tetsuya S. Tanaka, Sandy D. Der, Quaid Morris, Timothy R. Hughes, Peter W. Zandstra, and William L. Stanford. (2007) Prediction and Testing of Novel Transcriptional Networks Regulating Embryonic Stem Cell Self-Renewal and Commitment. Cell Stem Cell, Vol 1, 71-86, 07 June. | University of Toronto | Link | | | Davey RE, Onishi K, Mahdavi A, Zandstra PW. (2007) LIF-mediated control of embryonic stem cell self-renewal emerges due to an autoregulatory loop. FASEB J. Jul;21(9):2020-32. | Univerity of Toronto | Link | | | Low J, Huang S, Dowless M, Blosser W, Vincent T, Davis S, Hodson J, Koller E, Marcusson E, Blanchard K, Stancato L. (2007) High-Content Imaging Analysis of the Knockdown Effects of Validated siRNAs and Antisense Oligonucleotides. J Biomol Screen. May 21. | Eli Lilly and Company | Link | | | Mahdavi A, Davey RE, Bhola P, Yin T, Zandstra PW. (2007) Sensitivity Analysis of Intracellular Signaling Pathway Kinetics Predicts Targets for Stem Cell Fate Control. PLoS Comput Biol. Jul 6;3(7):e130. | University of Toronto and The University of Japan | Link | | | Vogt A, Lazo JS. (2007) Discovery of protein kinase phosphatase inhibitors. Methods Mol Biol.;356:389-400. | University of Pittsburgh | Link | | | Vogt A, Lazo JS. (2007) Implementation of high-content assay for inhibitors of mitogen-activated protein kinase phosphatases. Methods. Jul;42(3):268-77. | University of Pittsburgh | Link | | | Wang Z, McPherson PA, Raccor BS, Balachandran R, Zhu G, Day BW, Vogt A, Wipf P. (2007) Structure-activity and High-content Imaging Analyses of Novel Tubulysins. Chem Biol Drug Des. Aug;70(2):75-86. | University of Pittsburgh | Link | | | Kerrison JB, Zack DJ. (2007) Neurite outgrowth in retinal ganglion cell culture. Methods Mol Biol;356:427-34 | Wilmer Eye Institute, Johns Hopkins Hospital | Link | | | O'Brien P, Haskins JR. (2007) In vitro cytotoxicity assessment. Methods Mol Biol.;356:415-25. | Safety Sciences Europe, Pfizer Globral Research and Development | Link | | | Buckbinder L, Crawford DT, Qi H, Ke HZ, Olson LM, Long KR, Bonnette PC, Baumann AP, Hambor JE, Grasser WA, Pan LC, Owen TA, Luzzio MJ, Hulford CA, Gebhard DF, Paralkar VM, Simmons HA, Kath JC, Roberts WG, Smock SL, Guzman-Perez A, Brown TA, Li M. (2007) Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis. Proc Natl Acad Sci U S A. Jun 19;104(25):10619-24. | Pfizer Global Reseach and Development | Link | | | Liu D, McIlvain HB, Fennell M, Dunlop J, Wood A, Zaleska MM, Graziani EI, Pong K. (2007) Screening of immunophilin ligands by quantitative analysis of neurofilament expression and neurite outgrowth in cultured neurons and cells. J Neurosci Methods. Apr 5. | Neuroscience Discovery Research, Wyeth Research | Link | | | Taylor DL. (2007) Past, present, and future of high content screening and the field of cellomics. Methods Mol Biol.;356:3-18. | Cellumen, Inc. | Link | | | Dawes LJ, Angell H, Sleeman M, Reddan JR, Wormstone IM. (2007) TGFbeta isoform dependent Smad2/3 kinetics in human lens epithelial cells: a Cellomics analysis. Exp Eye Res. May;84(5):1009-12. | Cambridge Antibody Technology | Link | | | Stilwell JL, Guan Y, Neve RM, Gray JW. (2007) Systems biology in cancer research: genomics to cellomics. Methods Mol Biol. 356:353-65. | Lawrence Berkeley National Laboratory | Link | | | Diaz D, Scott A, Carmichael P, Shi W, Costales C. (2007) Evaluation of an automated in vitro micronucleus assay in CHO-K1 cells. Mutat Res. Feb 28. | Cerep, Inc. | Link | | | Park JY, Arnaout MA, Gupta V. (2007) A simple, no-wash cell adhesion-based high-throughput assay for the discovery of small-molecule regulators of the integrin CD11b/CD18. J Biomol Screen. Apr;12(3):406-17. | Harvard Medical School | Link | | | Rickardson L, Wickström M, Larsson R, Lövborg H. (2007) Image-Based Screening for the Identification of Novel Proteasome Inhibitors.J Biomol Screen. Mar;12(2):203-10 | Clinical Pharmacology University Hospital 581 85 Linköping Sweden | Link | | | Wickstrom M, Danielsson K, Rickardson L, Gullbo J, Nygren P, Isaksson A, Larsson R, Lovborg H. (2007) Pharmacological profiling of disulfiram using human tumor cell lines and human tumor cells from patients. Biochem Pharmacol. Jan 1;73(1):25-33. | University Hospital, Uppsala, Sweden | Link | | | Van Sant C, Wang G, Anderson MG, Trask OJ, Lesniewski R, Semizarov D. Endothelin signaling in osteoblasts: global genome view and implication of the calcineurin/NFAT pathway.Mol Cancer Ther. 2007 Jan;6(1):253-61. | Abbott Laboratories | Link | |
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Peer-Reviewed Publications - 2006
| Author Affiliation | Website | PDF | | Harrison BC, Mi-Sung Kim, Eva van Rooij, Craig F. Plato, Philip J. Papst, Rick B. Vega, John A. McAnally, James A. Richardson, Rhonda Bassel-Duby, Eric N. Olson, and Timothy A. McKinsey. (2006) Regulation of Cardiac Stress Signaling by Protein Kinase D1. Mol. Cell. Biol., May 2006; 26: 3875 - 3888. | Myogen | Link | | | Vidali L, Feng Chen, Gregor Cicchetti, Yasutaka Ohta, and David J. Kwiatkowski. (2006) Rac1-null Mouse Embryonic Fibroblasts Are Motile and Respond to Platelet-derived Growth Factor. Mol. Biol. Cell, May 2006; 17: 2377 - 2390. | Brigham and Women's Hospital and Harvard Medical School | Link | | | Lamian V, Rich A, Ma Z, Li J, Seethala R, Gordon D, and Dubaquie Y. (2006) Characterization of Agonist-Induced Motilin Receptor Trafficking and Its Implications for Tachyphylaxis. Mol. Pharmacol., 69: 109 - 118. | Bristol Myers Squibb | Link | | | Davey RE, Zandstra PW. (2006) Spatial organization of embryonic stem cell responsiveness to autocrine gp130 ligands reveals an autoregulatory stem cell niche. Stem Cells. Nov;24(11):2538-48. | Institute of Biomaterials and Biomedical Engineering, University of Toronto | Link | | | Yan P, Nanamori M, Sun M, Zhou C, Cheng N, Li N, Zheng W, Xiao L, Xie X, Ye RD, and Wang MW. (2006) The Immunosuppressant Cyclosporin A Antagonizes Human Formyl Peptide Receptor through Inhibition of Cognate Ligand Binding. J. Immunol., 177: 7050 - 7058. | National Center for Drug Screening, China | Link | | | Culbert AA, Skaper SD, Howlett DR, Evans NA, Facci L, Soden PE, Seymour ZE, Guillot F, Gaestel M, and Richardson JC. (2006) MAPK-activated protein kinase 2 deficiency in microglia inhibits pro-inflammatory mediator release and resultant neurotoxicity. Relevance to neuroinflammation in a transgenic mouse model of Alzheimer disease. J. Biol. Chem., 281: 23658 - 23667. | GlaxoSmithKline Research and Development Limited | Link | | | Qian MD, Jie Zhang, Xiang-Yang Tan, Andrew Wood, Davinder Gill, and Seongeun Cho. (2006) Novel Agonist Monoclonal Antibodies Activate TrkB Receptors and Demonstrate Potent Neurotrophic Activities. J. Neurosci., Sep 2006; 26: 9394 - 9403. | Wyeth Research | Link | | | Fryknäs M, Rickardson L, Wickström M, Dhar S, Lövborg H, Gullbo J, Nygren P, Gustafsson MG, Isaksson A, Larsson R. (2006) Phenotype-based screening of mechanistically annotated compounds in combination with gene expression and pathway analysis identifies candidate drug targets in a human squamous carcinoma cell model. J Biomol Screen. Aug;11(5):457-68. | Department of Genetics and Pathology, Uppsala University | Link | | | Park HJ, Partridge E, Cheung P, Pawling J, Donovan R, Wrana JL, Dennis JW. (2006) Chemical enhancers of cytokine signaling that suppress microfilament turnover and tumor cell growth. Cancer Res. Apr 1;66(7):3558-66. | University of Toronto | Link | | | Trask OJ Jr, Baker A, Williams RG, Nickischer D, Kandasamy R, Laethem C, Johnston PA, Johnston PA. (2006) Assay development and case history of a 32K-biased library high-content MK2-EGFP translocation screen to identify p38 mitogen-activated protein kinase inhibitors on the ArrayScan 3.1 imaging platform. Methods Enzymol;414:419-39. | Eli Lilly and Company | Link | | | Nickischer D, Laethem C, Trask OJ Jr, Williams RG, Kandasamy R, Johnston PA, Johnston PA. (2006) Development and implementation of three mitogen-activated protein kinase (MAPK) signaling pathway imaging assays to provide MAPK module selectivity profiling for kinase inhibitors: MK2-EGFP translocation, c-Jun, and ERK activation. Methods Enzymol;414:389-418. | Eli Lilly and Company | Link | | | Williams RG, Kandasamy R, Nickischer D, Trask OJ Jr, Laethem C, Johnston PA, Johnston PA. (2006) Generation and characterization of a stable MK2-EGFP cell line and subsequent development of a high-content imaging assay on the Cellomics ArrayScan platform to screen for p38 mitogen-activated protein kinase inhibitors. Methods Enzymol. ;414:364-89. | Eli Lilly and Company | Link | | | Borchert KM, Sells Galvin RJ, Hale LV, Trask OJ, Nickischer DR, Houck KA. (2006) Screening for activators of the wingless type/Frizzled pathway by automated fluorescent microscopy.Methods Enzymol. ;414:140-50. | Eli Lilly and Company | Link | | | Lundholt BK, Heydorn A, Bjørn SP, Praestegaard M. (2006) A simple cell-based HTS assay system to screen for inhibitors of p53-Hdm2 protein-protein interactions. Assay Drug Dev Technol. Dec;4(6):679-88. | BioImage | Link | | | Grånäs C, Lundholt BK, Loechel F, Pedersen HC, Bjørn SP, Linde V, Krogh-Jensen C, Nielsen EM, Praestegaard M, Nielsen SJ. (2006) Identification of RAS-mitogen-activated protein kinase signaling pathway modulators in an ERF1 redistribution screen. J Biomol Screen. Jun;11(4):423-34. | BioImage | Link | | | Richards GR, Smith AJ, Parry F, Platts A, Chan GK, Leveridge M, Kerby JE, Simpson PB. (2006) A morphology- and kinetics-based cascade for human neural cell high content screening. Assay Drug Dev Technol. Apr;4(2):143-52. | The Neuroscience Research Centre, Merck Sharp and Dohme Research Laboratories, Harlow, Essex, UK. | Link | | | Zhang T, Stilwell JL, Gerion D, Ding L, Elboudwarej O, Cooke PA, Gray JW, Alivisatos AP, Chen FF (2006) Cellular effect of high doses of silica-coated quantum dot profiled with high throughput gene expression analysis and high content cellomics measurements. Nano Lett. Apr;6(4):800-8. | Lawrence Berkeley National Laboratory | Link | | | Fowler A, Seifert N, Acker V, Woehrle T, Kilpert C, de Saizieu A. (2006) A Nonradioactive High-Throughput / High-Content Assay for Measurement of the Human Serotonin Reuptake Transporter Function In Vitro. J Biomol Screen. Nov 12. | DSM Nutritional Products | Link | | | Richards GR, Smith AJ, Cuddon P, Ma QP, Leveridge M, Kerby J, Roderick HL, Bootman MD, Simpson PB. (2006) The JAK3 inhibitor WHI-P154 prevents PDGF-evoked process outgrowth in human neural precursor cells. J Neurochem. Apr;97(1):201-10. | Merck and Co | Link | | | Hassan SB, Lovborg H, Lindhagen E, Karlsson MO, Larsson R. (2006) CHS 828 kill tumour cells by inhibiting the nuclear factor-kappaB translocation but unlikely through down-regulation of proteasome. Anticancer Res. Nov-Dec;26(6B):4431-6 | University Hospital, Uppsala, Sweden | Link | | | William J. Buchser, Jose R. Pardinas, Yan Shi, John L. Bixby, and Vance P. Lemmon. (2006) 96-Well electroporation method for transfection of mammalian central neurons. BioTechniques® November Volume 41, Number 5: pp 619-624 | University of Miami | Link | | | Grove LE, Ghosh RN. (2006) Quantitative characterization of mitosis-blocked tetraploid cells using high content analysis. Assay Drug Dev Technol. Aug;4(4):421-42 | Cellomics Inc. | Link | | | Soncini C, Carpinelli P, Gianellini L, Fancelli D, Vianello P, Rusconi L, Storici P, Zugnoni P, Pesenti E, Croci V, Ceruti R, Giorgini ML, Cappella P, Ballinari D, Sola F, Varasi M, Bravo R, Moll J. (2006) PHA-680632, a novel Aurora kinase inhibitor with potent antitumoral activity. Clin Cancer Res. Jul 1;12(13):4080-9. | Nerviano Medical Sciences | Link | | | Willmarth NE, Ethier SP. (2006) Autocrine and juxtacrine effects of amphiregulin on the proliferative, invasive, and migratory properties of normal and neoplastic human mammary epithelial cells. J Biol Chem. Oct 10 | University of Michigan and Wayne State University School of Medicine | Link | | | Ross S, Chen T, Yu V, Tudor Y, Zhang D, Liu L, Tamayo N, Dominguez C, Powers D. (2006) High-Content Screening Analysis of the p38 Pathway: Profiling of Structurally Related p38alpha Kinase Inhibitors Using Cell-Based Assays. Assay Drug Dev Technol. Aug;4(4):397-409 | Amgen | Link | | | Bokhari SM, Zhou L, Karasek MA, Paturi SG, Chaudhuri V. (2006) Regulation of skin microvasculature angiogenesis, cell migration, and permeability by a specific inhibitor of PKCalpha. J Invest Dermatol. Feb;126(2):460-7 | Stanford University School of Medicine | Link | | | Wipf P, Graham TH, Vogt A, Sikorski RP, Ducruet AP, Lazo JS (2006) Cellular analysis of disorazole C and structure-activity relationship of analogs of the natural product. Chem Biol Drug Des 67(1):66-73 | University of Pittsburgh | Link | | | Gasparri F, Cappella P, Galvani A. (2006) Multiparametric Cell Cycle Analysis by Automated Microscopy. J Biomol Screen. Sep;11(6):586-98. | Nerviano Medical Sciences | Link | | | O'Brien PJ, Irwin W, Diaz D, Howard-Cofield E, Krejsa CM, Slaughter MR, Gao B, Kaludercic N, Angeline A, Bernardi P, Brain P, Hougham C. (2006) High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening. Arch Toxicol. Apr 6 DOI: 10.1007/s00204-006-0091-3 | Pfizer | Link | | | Inglefield JR, Larson CJ, Gibson SJ, Lebrec H, Miller RL. (2006) Apoptotic Responses in Squamous Carcinoma and Epithelial Cells to Small-Molecule Toll-like Receptor Agonists Evaluated with Automated Cytometry. J Biomol Screen. Sep;11(6):575-85 | 3M Pharmaceuticals | Link | | | Wheeler RT, Fink GR. (2006) A drug-sensitive genetic network masks fungi from the immune system. PLoS Pathog. Apr;2(4):e35. | Whitehead Institute for Biomedical Research | Link | | | Amy Barabasz, Briana Foley, James C. Otto, Anisa Scott, John Rice. (2006) The Use of High-Content Screening for the Discovery and Characterization of Compounds That Modulate Mitotic Index and Cell Cycle Progression by Differing Mechanisms of Action. ASSAY and Drug Development Technologies. Apr 2;Vol. 4, No. 2: 153-163 | Serenex | Link | | | McIlvain HB, Baudy A, Sullivan K, Liu D, Pong K, Fennell M, Dunlop J. (2006) Pituitary adenylate cyclase-activating peptide (PACAP) induces differentiation in the neuronal F11 cell line through a PKA-dependent pathway. Brain Res. 1077(1):16-23. | Wyeth | Link | | | Fennell M, Chan H, Wood A. (2006) Multiparameter measurement of caspase 3 activation and apoptotic cell death in NT2 neuronal precursor cells using high-content analysis. J Biomol Screen. Apr;11(3):296-302. | Wyeth | Link | | | Morelli JK, Buehrle M, Pognan F, Barone LR, Fieles W, Ciaccio PJ. (2006) Validation of an in vitro screen for phospholipidosis using a high-content biology platform. Cell Biol Toxicol. Jan;22(1):15-27. | AstraZeneca | Link | | | Moffat J, Grueneberg DA, Yang X, Kim SY, Kloepfer AM, Hinkle G, Piqani B, Eisenhaure TM, Luo B, Grenier JK, Carpenter AE, Foo SY, Stewart SA, Stockwell BR, Hacohen N, Hahn WC, Lander ES, Sabatini DM, Root DE. (2006). A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen. Cell. 2006 Mar24: 1283-1298. | MIT | Link | | | Morelli JK, M Buehrle, F Pognan, LR Barone, W Fieles, PJ Ciaccio (2006). Validation of an in vitro screen for phospholipidosis using a high-content biology platform. Cell Biol Toxicol. 2006 Jan;22(1):15-27. | Safety Assessment, US | Link | | | Volkov Y, A Long, M Freeley, L Golden-Mason, C O'Farrelly, A Murphy, D Kelleher (2006). The hepatitis C envelope 2 protein inhibits LFA-1-transduced protein kinase C signaling for T-lymphocyte migration. Gastroenterology. 2006 Feb;130(2):482-92. | Trinity College | Link | | | Tao R, L Wang, CH Chen, SH Wang, RA Demarco, MT Lotze, NL Thai, JJ Fung, L Lu, S Qian (2006). Mechanistic insights into achievement of cardiac allograft long-term survival by treatment with immature dendritic cells and sub-dose sirolimus. J Heart Lung Transplant. 2006 Mar;25(3):310-9. | University of Pittsburgh | Link | | | Björklund M, M Taipale, M Varjosalo, J Saharinen, J Lahdenperä and J Taipale (2006) Identification of pathways regulating cell size and cell-cycle progression by RNAi. Nature 439:1009-1013. | Biomedicum Helsinki | Link | | | Lovborg H, F Oberg, L Rickardson, J Gullbo, P Nygren, R Larsson (2006) Inhibition of proteasome activity, nuclear factor-KappaB translocation and cell survival by the antialcoholism drug disulfiram. Int J Cancer 118(6): 1577-80. | Uppsala University | Link | |
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Peer-Reviewed Publications - 2005
| Publication | Author Affiliation | Website | PDF | | Tian Q, Li J, Xie X, Sun M, Sang H, Zhou C, An T, Hu L, Ye RD, and Wang MW. (2005) Stereospecific Induction of Nuclear Factor- B Activation by Isochamaejasmin. Mol. Pharmacol., 68: 1534 - 1542 | National Center for Drug Screening, China | Link | | | Doshna CM, Shen AC, Gebhard DF, Brees DJ, and Somps CJ. (2005) Investigating Markers of DNA Oxidation, Lipid Peroxidation and Stress Response in Human Lens Epithelial Cell Lines. Invest. Ophthalmol. Vis. Sci., 46: 3850. | Pfizer Global Research and Development | Link | | | Pece-Barbara N, Vera S, Kathirkamathamby K, Liebner S, Di Guglielmo GM, Dejana E, Wrana JL, and Letarte M. (2005) Endoglin Null Endothelial Cells Proliferate Faster and Are More Responsive to Transforming Growth Factor 1 with Higher Affinity Receptors and an Activated Alk1 Pathway. J. Biol. Chem., 280: 27800 - 27808. | Mount Sinai Hospital, University of Toronto and University of Milan | Link | | | Lotharius J, Falsig J, van Beek J, Payne S, Dringen R, Brundin P, Leist M. (2005) Progressive degeneration of human mesencephalic neuron-derived cells triggered by dopamine-dependent oxidative stress is dependent on the mixed-lineage kinase pathway. J Neurosci. Jul 6;25(27):6329-42. | Department of Disease Biology, H. Lundbeck A/S | Link | | | Vogt A, Tamewitz A, Skoko J, Sikorski RP, Giuliano KA, Lazo JS. (2005) The benzo[c]phenanthridine alkaloid, sanguinarine, is a selective, cell-active inhibitor of mitogen-activated protein kinase phosphatase-1. J Biol Chem. May 13;280(19):19078-86. | University of Pittsburgh | Link | | | Kerrison JB, Lewis RN, Otteson DC, Zack DJ. (2005) Bone morphogenetic proteins promote neurite outgrowth in retinal ganglion cells. Mol Vis. Mar 18;11:208-15. | Johns Hopkins University School of Medicine | Link | | | Hirasawa A, Tsumaya K, Awaji T, Katsuma S, Adachi T, Yamada M, Sugimoto Y, Miyazaki S, Tsujimoto G. (2005) Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120.Nat Med. Jan;11(1):90-4. | National Research Institute for Child Health and Development, Japan | Link | | | Bova MP, Tam D, McMahon G, Mattson MN.(2005). Troglitazone induces a rapid drop of mitochondrial membrane potential in liver HepG2 cells. Toxicology Letters.(155) 2005 | Sugen | Link | | Ilyin SE, Horowitz D, Belkowski SM, Xin H, Eckardt AJ, Darrow AL, Chen C, Maley D, D'Andrea M, Plata-Salaman CR, Derian CK (2005). Integrated expressional analysis: application to the drug discovery process.
Methods. 37(3):280-8. | Johnson & Johnson | Link | | | Giuliano KA, WS Cheung, DP Curran, BW Day, AJ Kassick, JS Lazo, SG Nelson, Y Shin, DL Taylor (2005) Systems Cell Biology Knowledge Created from High Content Screening. Assay Drug Dev Technol. 3:501-514 | Cellumen, University of Pittsburgh, Carnegie Mellon University | Link | | | Morelock MM, EA Hunter, TJ Moran, S Heynen, C Laris, M Thieleking, M Akong, I Mikic, S Callaway, RP DeLeon, A Goodacre, D Zacharias, JH Price (2005) Statistics of Assay Validation in High Throughput Cell Imaging of Nuclear Factor κB Nuclear Translocation. Assay Drug Dev Technol. 3:483-499. | Boehringer Ingelheim | Link | | | Vasudevan C, N Fursov, P Maunder, M Cong, M Federici, JR Haskins, T Livelli, Z Zhong (2005) Improving High-Content-Screening Assay Performance by Using Division-Arrested Cells. Assay Drug Dev Technol. 3:515-523. | Cellomics, Inc., Cell & Molecular Technologies, Inc. | Link | | | Bertelsen M and A Sanfridson (2005) Inflammatory Pathway Analysis Using a High Content Screening Platform. Assay Drug Dev Technol. 3:261-271. | AstraZeneca, Lund | Link | | | Lovborg H, J Gullbo, R Larsson (2005) Screening for apoptosis-classical and emerging techniques. Anticancer Drugs 16:593-9. | Uppsala Univeristy | Link | | | Ghosh RN, R DeBiasio, CC Hudson, ER Ramer, CL Cowan, RH Oakley.(2005) Quantitative Cell-Based High-Content Screening for Vasopressin Receptor Agonists Using Transfluor Technology. J Biomol Screen. Aug.10(5):476-84. | Cellomics, Inc, Norak Biosciences, Inc. | Link | | | Borchert KM, Galvin RJ, Frolik CA, Hale LV, DL Halladay, RJ Gonyier, OJ Trask, DR Nickischer, KA Houck. (2005) High-content screening assay for activators of the wnt/fzd pathway in primary human cells. Assay Drug Dev Technol. (2):133-41. | Lilly Research Laboratories, Eli Lilly & Co. | Link | | | Grace MJ, Lee S, Bradshaw S, Chapman J, Spond J, Cox S, Delorenzo M, Brassard D, Wylie D, Cannon-Carlson S, Cullen C, Indelicato S, Voloch M, Bordens R (2005) Site of pegylation and polyethylene glycol molecule size attenuate interferon-alpha antiviral and antiproliferative activities through the JAK/STAT signaling pathway. J Biol Chem. 280:6327-36. | Schering-Plough Research Institute | Link | |
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Peer-Reviewed Publications - 2004
| Publication | Author Affiliation | Website | PDF | | Falsig J, Pörzgen P, Lotharius J, and Leist M. (2004) Specific Modulation of Astrocyte Inflammation by Inhibition of Mixed Lineage Kinases with CEP-1347. J. Immunol., 173: 2762 - 2770. | Department of Neuropathology, University of Zürich | Link | | | Vega RB, Harrison BC, Meadows E, Roberts CR, Papst PJ, Olson EN, and McKinsey TA. (2004) Protein Kinases C and D Mediate Agonist-Dependent Cardiac Hypertrophy through Nuclear Export of Histone Deacetylase 5. Mol. Cell. Biol., 24: 8374 - 8385. | University of Texas Southwestern Medical Center and Myogen | Link | | | Swallow CJ, Partridge EA, Macmillan JC, Tajirian T, DiGuglielmo GM, Hay K, Szweras M, Jahnen-Dechent W, Wrana JL, Redston M, Gallinger S, and Dennis JW. (2004) {alpha}2HS-glycoprotein, an Antagonist of Transforming Growth Factor ß In vivo, Inhibits Intestinal Tumor Progression. Cancer Res., Sep 2004; 64: 6402 - 6409. | Mount Sinai Hospital | Link | | | Alexander L. Friedman , Richard DeBiasio and Richik N. Ghosh (2004) High Content Screening (HCS) Bioassays Enabled through Application of Grating Illumination Technique to Fluorescence Microscopy. Microscopy and Microanalysis, 10: 1552-1553 | Cellomics, Inc. | Link | | | Fredericks ZL, Forte C, Capuano IV, Zhou H, Bos TV, and Carter P. (2004) Identification of potent human anti-IL-1RI antagonist antibodies. Protein Eng. Des. Sel., 17: 95 - 106. | Amgen | Link | | | Xin H, Bernal A, Amato FA, Pinhasov A, Kauffman J, Brenneman DE, Derian CK, Andrade-Gordon P, Plata-Salamán CR, Ilyin SE. (2004) High-throughput siRNA-based functional target validation. J Biomol Screen. Jun;9(4):286-93. | Johnson & Johnson Pharmaceutical Research & Development | Link | | | Chuma M, Sakamoto M, Yasuda J, Fujii G, Nakanishi K, Tsuchiya A, Ohta T, Asaka M, Hirohashi S. (2004) Overexpression of cortactin is involved in motility and metastasis of hepatocellular carcinoma. J Hepatol. 2004 Oct;41(4):629-36. | National Cancer Center Research Institute, Japan | Link | | | Koide N. (2004) Automated live-cell and kinetic fluorescence image analysis system--KineticScan HCS Reader. Tanpakushitsu Kakusan Koso. 2004 Aug;49(11 Suppl):1656-7 | Article in Japanese | Link | | | Xua JJ, D Diaz, PJ O’Brien (2004) Applications of cytotoxicity assays and pre-lethal mechanistic assays for assessment of human hepatotoxicity potential. Chemico-Biol. Int 150: 115-128. | Pfizer, Inc and Cerep | Link | | | Chang KH, PW Zandstra (2004) Quantitative Screening of Embryonic Stem Cell Differentiation: Endoderm Formation as a Model. Biotechnol Bioeng. 88:287-98. | University of Toronto | Link | | | Schlag BD, Z Lou, M Fennell, J Dunlop (2004). Ligand dependency of 5-HT2C receptor internalization. J Pharmacol Exp Ther. 310:865-870. | Wyeth Research | Link | | | Partridge EA, C Le Roy, GM Di Guglielmo, J Pawling, P Cheung, M Granovsky, IR Nabi, JL Wrana, JW Dennis (2004) Regulation of cytokine receptors by Golgi N-glycan processing and endocytosis. Science 306(5693):120-4. | Mt Sinai Hospital | Link | | | Vakkila J, RA DeMarco, MT Lotze (2004) Imaging analysis of STAT1 and NF-kB translocation in dendritic cells at the single cell level. J Immunol Methods 294:123-134. | University of Pittsburgh Molecular Medicine Institute | Link | | | Mastyugin V, E McWhinnie, M Labow, F Buxton (2004) A Quantitative High-Throughput Endothelial Call Migration Assay. J. Biomol Screen 9:712-718. | Novartis Institutes for Biomedical Research, Cambridge MA | Link | | | Vogt A, EN Kalb, JS Lazo (2004) A scalable high-content cytotoxicity assay insensitive to changes in mitochondrial metabolic activity. Oncol Res.14:305-14. | University of Pittsburgh | Link | | | Ghosh RN, L Grove, O Lapets (2004) A Quantitative Cell-Based High-Content Screening Assay for the Eperidermal Growth Factor Receptor-Specific Activiation of Mitogen-Activated Protein Kinase. Assay Drug Dev Tech 2:473-481. | Cellomics, Inc. | Link | | | Richards GR, RM Millard, M Leveridge, J Kerby, PB Simpson (2004). Quantitative Assays of Chemotaxis and Chemokinesis for Human Neural Cells. Assay Drug Dev Tech 2: 465-472. | Merck | Link | | | Tencza SB and MA Sipe (2004) Detection and Classification of Threat Agents via High-Content Assays of Mammalian Cells. J. Appl. Tox. 24: 371-377. | Cellomics, Inc. | Link | | | Nam J-S, Y Ino, Y Kanai, M Sakamoto, S Hirohashi (2004) 5-aza-2'-deoxycytidine restores the E-cadherin system in E-cadherin-silenced cancer cells and reduces cancer metastasis. Clin Exp Metastasis 21:49-56. | National Cancer Research Institute; Keio University, Japan | Link | | | Abraham V, B Samson, O Lapets, JR Haskins (2004) Automated Classification of Individual Cellular Responses Across Multiple Targets. Preclinica 2:349-355. | Cellomics, Inc. | Link | PDF (399kB) | | Guiliano K, Y-T Chan, DL Taylor (2004) High-Content Screening with siRNA Optimizes a Cell Biological Approach to Drug Discovery: Defining the Roll of p53 Activation in the Cellular Response to Anticancer Drugs. J Biolmol Screening 9:557-568. | Cellomics, Inc. | Link | | | Lovborg, H, P Nygren, and R Larsson. (2004) Multiparametric evaluation of apoptosis: effects of standard cytotoxic agents and the cyanoguanidine CHS 828. Mol. Cancer Ther. 3:521-526. | Uppsala University | Link | | | Bhawe, KM, RA Blake, DO Clary, PM Flanagan. (2004) An Automated Image Capture and Quantitation Approach to Identify Proteins Affecting Tumor Cell Proliferation. J Biomol Screen 9:216-222. | Sugen | Link | | | Gasparri, F, M Mariani, F Sola and A Galvani. (2004) Quantification of the proliferation index of human dermal fibroblast cultures with the ArrayScan high content screening reader. J Biomol Screen 9:232-243. | Nerviano (Pharmacia) Italy | Link | |
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Peer-Reviewed Publications - 2003
| Publication | Author Affiliation | Website | PDF | | Gullbo J, Wallinder C, Tullberg M, Lövborg H, Ehrsson H, Lewensohn R, Nygren P, Luthman K, and Larsson R. (2003) Antitumor activity of the novel melphalan containing tripeptide J3 (L-prolyl-L-melphalanyl-p-L-fluorophenylalanine ethyl ester): Comparison with its m-L-sarcolysin analogue P2. Mol. Cancer Ther. 2: 1331. | Uppsala University | Link | | | Dahl JP, Wang-Dunlop J, Gonzales C, Goad MEP, Mark RJ, and Kwak SP. (2003) Characterization of the WAVE1 Knock-Out Mouse: Implications for CNS Development. J. Neurosci., 23: 3343. | Wyeth Research | Link | | | Minguez, JM, SY Kim, KA Giuliano, R Balachandran, C Madiraju, BW Day, and DP Curran. (2003) Synthesis and biological assessment of simplified analogues of the potent microtubule stabilizer (+)-discodermolide. Bioorg Med Chem. 11:3335-57. | University of Pittsburgh | Link | | | Vogt, A, KA Cooley, M Brisson, MG Tarpley, P Wipf, and JS Lazo. (2003) Cell-active dual specificity phosphatase inhibitors identified by high-content screening. Chem Biol. 10:733-42. | University of Pittsburgh | Link | | | Kawamura, YI, R Kawashima, Y Shirai, R Kato, T Hamabata, M Yamamoto, K Furukawa, K Fujihashi, JR McGhee, H Hayashi, T Dohi. (2003) Cholera toxin activates dendritic cells through dependence on GM1-ganglioside which is mediated by NF-kB translocation. Eur. J. Immunol. 33:3205-3212. | International Medical Center of Japan, Tokyo | Link | | | Li Z, Y Yan, EA Powers, X Ying, K Janjua, T Garyantes, B Baron. (2003) Identification of gap junction blockers using automated fluorescence microscopy imaging. J Biomol Screen 8:489-499. | Aventis | Link | | | Giuliano, KA, JR Haskins and DL Taylor. (2003) Advances in high content screening for drug discovery. Assay and Drug Development Technologies. 1:565-577. | Cellomics, Inc. | Link | | | Giuliano KA. (2003) High-content profiling of drug-drug interactions: cellular targets involved in the modulation of microtubule drug action by the antifungal ketoconazole. J Biomol Screen 8:125-35. | Cellomics, Inc. | Link | |
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Peer-Reviewed Publications - 2002
| Publication | Author Affiliation | Website | PDF | | Parrish-Novak J, W Xu, T Brender, L Yao, C Jones, J West, C Brandt, L Jelinek, K Madden, PA McKernan, DC Foster, S Jaspers, YA Chandrasekher; ZymoGenetics, Inc. (2002) Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions. J Biol Chem. 277(49):47517-23. | ZymoGenetics | Link | PDF (288kB) | | Minguez, JM, KA Giuliano, R Balachandran, C Madiraju, DP Curran, and BW Day. (2002) Synthesis and high content screening of simplified analogues of the potent microtubule stabilizer (+)-discodermolide. Mol Cancer Ther 1:1305-1313. | University of Pittsburgh | Link | PDF (224kB) | | Arden, SR, P Janardhan, R DiBiasio, B Arnold, RN Ghosh. (2002) An Automated Quantitative High Content Screening Assay for Neurite Outgrowth. Chemistry Today 20:64-66. | Cellomics, Inc. | | | | Kapur, R. (2002) Fluorescence imaging and engineered biosensors: functional and activity-based sensing using high content screening. Ann NY Acad Sci 961:196-197. | Cellomics, Inc. | Link | |
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Peer-Review Publications - 2001
| Publication | Author Affiliation | Website | PDF | | Honma K, T Ochiyab, S Nagaharac, A Sanoc, H Yamamotob, K Hiraib, Y Asoa, M Teradab (2001) Atelocollagen-Based Gene Transfer in Cells Allows High-Throughput Screening of Gene Functions. Biochem Biophys Res Commun. 289:1075-81. | Koken Bioscience Institute; National Cancer Center Research Institute, Japan | Link | | | Chen J, Zhong Q, Wang J, Cameron RS, Borke JL, Isales CM, Bollag RJ. (2001) Microarray analysis of Tbx2-directed gene expression: a possible role in osteogenesis. Mol Cell Endocrinol 177:43-54. | Medical College of Georgia | Link | | | Haskins JR, Rowse P, Rahbari R, de la Iglesia FA. (2001) Thiazolidinedione toxicity to isolated hepatocytes revealed by coherent multiprobe fluorescence microscopy and correlated with multiparameter flow cytometry of peripheral leukocytes. Arch Toxicol 75(7):425-38. | Pfizer | Link | | | Blumberg, H, D Conklin, WF Xu, A Grossmann, T Brender, S Carollo, M Eagan, D Foster, BA Haldeman, A Hammond, H Haugen, L Jelinek, JD Kelly, K Madden, MF Maurer, J Parrish-Novak, D Prunkard, S Sexson, C Sprecher, K Waggie, J West, TE Whitmore, L Yao, MK Kuechle, BA Dale and YA Chandrasekher. (2001) Interleukin 20: Discovery, receptor identification, and role in epidermal function. Cell 104:9. | Zymogenetics, Inc. | Link | | | Vogt, A, T Adachi, AP Ducruet, J Chesebrough, K Nemoto, BI Carr, and JS Lazo. (2001) Spatial analysis of key signaling proteins by High-content solid phase cytometry in Hep3B cells treated with an inhibitor of cdc2 dual-specificity phosphatases. J Biol Chem 276:20544-20550. | University of Pittsburgh | Link | PDF (504kB) | | Simpson PB, JI Bacha, EL Palfreyman, AJ Woollacott, RM McKernan, J Kerby. (2001) Retinoic acid-evoked differentiation of neuroblastoma cells predominates over growth factor stimulation: an automated image capture and quantitation approach to neuritogenesis. Anal. Biochem. 298:163-169. | Merck Sharp & Dohme | Link | | | Conway BR, Minor LK, Xu JZ, D'Andrea MR, Ghosh RN, Demarest KT. (2001) Quantitative analysis of agonist-dependent parathyroid hormone receptor trafficking in whole cells using a functional green fluorescent protein conjugate. J Cell Physiol 189:341-355. | Johnson & Johnson | Link | |
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Peer-Review Publications - 1997-2000
| Publication | Author Affiliation | Website | PDF | | Wipf, P, JT Reeves, R Balachandran, KA Giuliano, E Hamel, and BW Day. (2000) Synthesis and biological evaluation of a focused mixture library of analogues of the antimitotic marine natural product curacin A. J Amer Chem Soc 122:9391. | University of Pittsburgh | Link | | | Ghosh, RN, Y-T Chen, R DeBiasio, RL DeBiasio, BR Conway, LK Minor, and KT Demarest. (2000) Cell-based, high content screen for receptor internalization, recycling and intracellular trafficking. Biotechniques 29:170-175. | Cellomics, Inc. | Link | PDF (324kB) | | Breider MA, Gough AW, Haskins JR, Sobocinski G, de la Iglesia FA. (1999) Troglitazone-induced heart and adipose tissue cell proliferation in mice. Toxicol Pathol. 27(5):545-52. | Parke-Davis | Link | | | Conway, BR, LK Minor, JZ Xu, JW Gunnet, R DeBiasio, MR D'Andrea, R Rubin, R DeBiasio, K Giuliano, L DeBiasio, and KT Demarest. (1999) Quantification of G-protein coupled receptor internalization using G-protein coupled receptor green fluorescent protein conjugate with the ArrayScan High Content Screening System. J Biomol Screen 4:75-86. | Johnson & Johnson | Link | | | Ding, GJF, PA Fischer, RC Boltz, JA Schmidt, JJ Colaianne, A Gough, RA Rubin, and DK Miller. (1998) Characterization and quantitation of NF-kB nuclear translocation induced by interleukin-1 and tumor necrosis factor-a, J Biol Chem 273:28897-28905. | Merck | Link | | | Giuliano, KA, RL DeBiasio, RT Dunlay, A Gough, JM Volosky, J Zock, GN Pavlakis, and DL Taylor. (1997) High Content Screening: A new approach to easing key bottlenecks in the drug discovery process. J Biomol Screen 2:249-259. | Cellomics, Inc. | Link | |
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