Why is it important to rule out acute porphyria disease? Because early and accurate diagnosis are paramount to providing the proper treatment. Symptoms of acute porphyria disease often mimic other common abdominal pain and neurological conditions. Left untreated or misdiagnosed the disease can lead to severe neurologic damage and even death. In addition, if treatment is started prior to testing for suspected porphyria disease, the results can be compromised. Don't compromise! If porphyria disease is suspected, use the Thermo Scientific Porphobilinogen (PBG) Test Kit on a random urine sample collected during the patient's attack. Results can be turned around in the lab in less than 20 minutes.
Product Detail
The porphyrias are a group of disorders which result from abnormalities in the biosynthesis of heme. They can be divided into two groups: the acute porphyrias and the non-acute porphyrias. During an acute attack of the heme precursor, porphobilinogen (PBG) accumulates in the liver and raised levels occur in the plasma and urine. An increase in urinary PBG, therefore, is strongly indicative of an acute porphyria attack.
The Thermo Scientific PBG Kit is intended to determine the presence of Porphobilinogen (PBG) in the urine within minutes. It is a rapid diagnostic assay that utilizes the Watson-Schwartz method. It is essentially an anion exchange resin that uses DMAB/acid solution to produce a color change when PBG is present in the urine. The test kit has at least a 15-month shelf life and can be stored at room temperature.
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