Standard RNA 2'-TBDMS, 2'-OMe and 2'-F Phosphoramidites
Thermo Scientific Standard RNA Phosphoramidites ensure quality and reliability for RNA oligonucleotide synthesis.
Product Detail
Rigorously controlled manufacturing processes minimize levels of reactive P(III) impurities which could be incorporated into the oligonucleotide product and/or result in the accumulation of by-products which can be difficult to remove during purification
NMR analysis is conducted on each lot to assure that the levels of critical impurities are within specifications
Process and Supply Chain Control:
Processes are strictly controlled and monitored from material procurement through final QC and product release under ISO9001 standards, providing batch-to-batch reproducibility
All standard RNA phosphoramidites are supplied with lot-specific quality control data including HPLC and phosphorous NMR analyses
2'-TBDMS:
TBDMS RNA amidite chemistry is the widely accepted standard for high quality, large-scale synthesis of RNA oligonucleotides
Specifications include limits for critical impurities
2'-OMe:
RNA oligonucleotides synthesized using 2'-OMe modified amidites are nuclease resistant, making them well suited for in vivo, antisense and aptamer applications
2'-F:
RNA oligonucleotides synthesized using 2'-Fluoro U and C phosphoramidites have increased thermal stability of RNA duplexes and nuclease resistance of single-stranded RNA
These phosphoramidites can be incorporated into custom siRNA oligonucleotides for use in gene-targeting and suppression studies
Flexible Packaging:
Common pack sizes fit most commercially available synthesizers and are in stock for immediate delivery
Custom and bulk packaging are available
Thermo Fisher Scientific (Milwaukee) is a licensed supplier of PAC protected and 2'-OMe phosphoramidites.
Standard RNA 2'-TBDMS, 2'-OMe and 2'-F Phosphoramidites
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