The Thermo Scientific Cellomics® ArrayScan® VTI is a modular high content screening instrument designed for high-capacity automated fluorescence imaging and quantitative analysis of fixed and live cells. The instrument features optics by Carl Zeiss®, broad spectrum white-light source, 12-bit cooled CCD camera, and integrated acquisition and analysis software. The instrument is a part of the Cellomics HCS Platform of instrumentation, automation, image analysis software (BioApplications), data management, cellular bioinformatics, HCS Reagent Kits and Cell Lines and Training & Support, that together form the most world’s most productive HCS platform.
Product Detail
The ArrayScan VTI is a flexible and reliable high throughput instrument for high content screening. It is automation friendly, and can integrate with Thermo Scientific and third-party devices. The ArrayScan VTI is ideal for a wide variety of HCS and HCA applications, in such areas as target identification, lead optimization, secondary screening, toxicity studies, and cell biology research.
The ArrayScan VTI has a scientific grade digital camera with multiple resolution modes. The system has an automated objective changer, allowing for control over optical resolution and field of view. It uses a high intensity white light source delivering a broad (350nm-700nm) illumination spectrum. The system includes a 10-position wheel for excitation filters and a 5-position turret for dichroic/emission cubes.
Modular Functionality
The ArrayScan VTI has a modular design that allows for easy system expansion. The system’s imaging, assay and data management capabilities can be expanded as needed, allowing the system to be utilized for a variety of HCS applications. Each component was designed and tested to be fully integrated with the instrument’s hardware and software.
ArrayScan VTI Modules
ApoTomeTM Optical Sectioning Device
Grating Imager
Reduces background fluorescence and removes out of focus light
Enables fine structure elucidation
Easy configuration for any assay and any channel
Live Cell Module
Offers full control of temperature (Ambient to 45°C), CO2 (0-10%) and added humidity (>90% relative humidity) to maintain optimal cell health
Proprietary cell tracking algorithm allows for both motility and kinetic measurements at the cell and well level
Cell movement can be monitored over seconds, minutes, hours or days
Automated Plate Handling
Robotics-ready and compatible with all major commercial laboratory robotic systems. The Thermo Scientific Catalyst Express integrates with the ArrayScan VTI quickly and easily to allow fast and reliable imaging around the clock.
Brightfield Module
Enables label-free analysis
A brightfield illuminator with a white light LED to visualize and capture non-fluorescent images
Focus, analyze and overlay brightfield and fluorescent images
Brightfield images can be analyzed with BioApplications – our portfolio of image analysis algorithms, validated for HCS
Emission Filter Wheel
6 position
Allows more flexible choices of filters
Address more biology, e.g. Quantum Dots, FRET
Liquid Handling Module
Single channel full function pipetting
Disposable tips
Flexible deck layout
Single-cell pharmacology
Explore more live cell and kinetic biology
Integrated Software
The ArrayScan VTI includes Thermo Scientific Cellomics iQ—High Content intelligent acquisition software. This integrated real-time image acquisition and data analysis software collects the images and data required for statistically robust and biologically relevant answers. It includes the proprietary auto-focus software Thermo Scientific Cellomics AccuFocus™, which provides fast focus on the biology in the well and can be used with a wide variety of plate types. Cellomics iQ can automate multiple protocols and automate changes to the objective and filter wheel, and its user-friendly menus are easy to navigate.
The ArrayScan VTI features the broadest portfolio of validated image analysis algorithms (BioApplications), allowing new users to get started with HCS immediately while providing experienced users with the flexibility to customize analysis. With the interactive rapid assay development environment users can optimize results quickly.
Thermo Scientific High-Content Informatics (HCi™) automatically stores and organizes data in an enterprise class database. Images and data are accessible to any authorized person in an organization with only a network connection. Analysis and visualization are available offline, and images from 3rd party sources can be imported into the database for analysis and storage.
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