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Amino Acid Side Chain Modification Agents
Reagents used to block amino acid side chains on proteins, change their charge, or change them to functional groups favorable for cross-linking and labeling.

Chaotropes, Protein Denaturants
Chaotropes such as urea or guanidine disrupt water interactions and help solubilize hydrophobic proteins and peptides. They also act as general protein denaturants, unfolding proteins and altering their three-dimensional structure.

Crosslinking Reagents
Chemical crosslinking agents are used to determine near-neighbor relationships, analyze three-dimensional structures of proteins and complexes, prepare antibody-enzyme conjugates, immobilize molecules and conjugate haptens to carrier proteins.

PEGylation Reagents
PEGylate peptides and proteins via available amine or sulfhydryl groups. Increase solubility and stability and reduce immunogenicity of peptides and proteins.

Proteases
Thermo Scientific Pierce offers proteinases for enzymatic cleavage of proteins to facilitate sequencing, amino acid analysis, structural analysis and various other applications. We offer proteases immobilized on agarose for easy removal of the protease following digestion.

Reducing Agents
Solution and solid-phase reducing agents, such as TCEP, DTT and mercaptoethanol, for disulfide-containing peptides and proteins.