MethElute Reagent (Trimethylanilinium Hydroxide [TMPAH])

• 0.2M trimethylanilnium hydroxide in methanol
• For the quantitative methylation and detection of barbiturates, sedatives, xanthine bases, phenolic alkaloids and dilantin by GC
• Eliminates troublesome secondary peaks
• When the reagent is heated in the injector port of a gas chromatograph with drug-containing extracts of serum or urine, the drugs containing reactive amino, hydroxyl or carboxyl groups will be converted to the corresponding methyl derivatives; these volatile methylated drugs or metabolites then pass through the chromatograph for separation and quantitation

MethElute™ reagent is a 0.2 molar trimethylanilinium hydroxide in methanol solution. When heated with drug-containing extracts of serum or urine, those drugs containing reactive amino, hydroxyl and carboxy functions will be methylated at these reactive sites. These methylated drugs are then analyzed by gas chromatography.