Easy and effective preparation of methyl esters from fatty acids and amino acids, phenols to methyl esters, thiols to mixed disulfides and certain diols to expides.
Methyl-8 Reagent - Quick Reference
Chemical Name:
N,N-Dimethylformamide dimethyl acetal
IUPAC Name:
N,N-dimethylformamide, 1,1-dimethoxyethane
Chemical Forumula:
C5H13NO2
Molecular Weight:
119.2
Boiling Point:
102 - 104°C
Density:
0.897
Product Detail
Highlights
Rapidly and conveniently converts carboxylic acids to methyl esters, primary amines to N,N-dimethylaminoethylene derivatives, phenols to methyl eters, thiols to thioethers, and certain diols to epoxides
Use with a solvent such as pyridine, DMF or acetonitrile; in most cases, reactions are repid, and quantitative yields are obtained as soon as the product/derivative is completely in solution
Methyl-8 Reagent offers significant advantages for preparing methyl esters for gas chromatography. The reaction is fast and complete upon dissolution. Yields are quantitative when reagent and sample are injected without prior mixing. Methyl-8 Reagent is packed in convenient, ready-to-use Hypo-Vial Sample Storage Vials and requires no water washing, extraction or concentration of the derivatives. In addition, no water is formed in the reaction. Reactions with Methyl-8 Reagent are usually complete upon dissolution. For long-chain solid acids, it is necessary to use Methyl-8 Reagent with additional solvent and mild heating, such as pyridine, benzene, methanol, chloroform, methylene chloride, THF and DMF.
References 1. Zhang, Y., et al. (1993). Assay of the acetyl-CoA probe acetyl-sulfamethoxazole and of sulfamethoxazole by gas chromatography-mass spectrometry. Anal. Biochem. 212, 481.
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