Converts carboxylic acids, phenols, sulfonamides and mercaptans to halogenated derivatives that are easily detected by electron capture.
PFBBr - Quick Reference
Chemical Name:
Pentafluorobenzyl bromide
IUPAC Name:
1-(bromomethyl)-2,3,4,5,6-pentafluoro-benzene
Chemical Forumula:
C7H2BrF5
Molecular Weight:
260.9
Boiling Point:
174 - 175°C
Density:
1.86
Product Detail
Highlights
For the conversion of carboxylic acids, phenols, sulfonamides and mercaptans to halogenated derivatives that are easily detected by electron capture.
Used to detect trace amounts of carboxylic acids, phenols and mercaptans in drinking water
Pentafluorobenzyl bromide (PFBBr), is used to convert carboxylic acids, phenols, sulfonamides and mercaptans to halogenated derivatives for electron capture detection (ECD) in GC analysis by an “extraction alkylation” technique. This process uses tetrabutylammonium as a counter ion and methylene chloride as a solvent. The use of PFBBr is ideal because reaction times are fast (~20 minutes) and derivatives are highly EC-sensitive, making them useful in low level determinations of fatty acids.
This reagent has been used with a potassium carbonate catalyst for the electron capture analysis of mercaptans, phenols and organic acids in surface water (1-3). PFBBr has been used in analyzing trace organics in asphalts as a “fingerprinting” technique for identifying asphalt pollutants found in surface water.
References 1. Kawahara, F.K. (1968). Microdetermination of derivatives of phenols and mercaptans by means of electron capture gas chromatography. Anal. Chem.40:1009-10. 2. Kawahara, F.K. (1968). Microdetermination of pentafluorobenzyl ester derivatives of organic acids by means of electron capture gas chromatography.Anal. Chem. 40:2073-5. 3. Kawahara F.K. (1976). Trace organic components as fingerprints in gas chromatographic identification of spilled asphalt. Environ. Sci & Tech. 10:761- 4. Bosin, T. R., et al. (1989). Harman in rat brain, lung and human CSF: effect of alcohol consumption. Alcohol 5: 505. 5. Jones, A. B., (1981). Determination of cannabidol in plasma by electron-capture gas chromatography. J. Chromatography 226: 99.
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