Silylation Grade Solvents

• Purified, dried and packaged under nitrogen in convenient Hypo-Vial Sample Storage Vials
• Use polar solvents (acetonitrile, dimethylformamide, dimethylsulfoxide, pyridine and tetrahydrofuran) to facilitate reactions; nonpolar organic solvent may be used, but they will not accelerate the rate of reaction
• Avoid water or alcohol because TMS reagents react with active hydrogen; avoid enolizable ketones
• Use dimethylformamide for steroids and other large molecules
• Use dimethylsulfoxide to prepare TMS derivatives of tertiary alcohols and some compound with reluctant solubility in other silylation solvents
• Pyridine is an excellent solvent and reaction medium for MS reactions and is an HCI acceptor in reactions involving organochlorosilanes
• Other commonly-used solvents include tetrahydrofuran and acetonitrile

* Dimethyl Sulfoxide is available in bulk quantities for manufacturing applications.