For alternative selectivity to traditional alkyl phases, we recommend you try the polar embedded phases of PRISM columns. The stationary phase contains urea groups embedded within the C12 chain, which extra interactions with samples to extend the capabilities of the phase.
PRISM RPN is a non-endcapped stationary phase, based on a highly base deactivated 100Å pore size silica. The pore size combined with the C12 phase gives the columns moderate hydrophobic retention for neutral samples, but compared to the conventional phases (C18 or C8) it offers a completely new selectivity.
A polar functional group between alkyl ligands and the silica surface allows fast analysis without compromising the resolving power. Additionally, the non-endcapped phase has extra polar selectivity, and is able to retain polar samples, and offer a slightly different elution profile to the PRISM RP phase. PRISM RPN is completely stable under 100% aqueous conditions, so it is ideal for 0 to 100% organic fast gradients.
Other column dimensions and hardware designs are available. Please contact us for more information if you do not see the exact column that you are interested in