The FAIMS interface works in combination with the H-ESI and APCI ion
probes on the TSQ Quantum series mass spectrometers to increase selectivity
in challenging assays. When used in combination with H-SRM, unsurpassed
selectivity and specificity are achieved.
Thermo Scientific ion trap mass spectrometers, when
coupled with the FAIMS interface, allow users to selectively isolate target
compounds based on a number of physical properties, including charge state and
molecular conformation.
Product Detail
The high-Field Asymmetric waveform Ion Mobility Spectrometry (FAIMS) interface is used in LC-MS method development to quickly and effectively resolve analytical challenges. The FAIMS interface is located in the atmospheric pressure region between the ion source and the mass spectrometer, providing a dimension of separation that is complementary with liquid chromatography and mass spectrometry. The increase in selectivity provided to LC-MS leads to accelerated method development and improved assay robustness.
The FAIMS interface provides an increase in selectivity by utilizing changes that occur in the behavior of an ion when subjected to alternating low and high electric fields. These changes in ion behavior are used by FAIMS to provide ion filtering, resulting in LC-MS chromatograms with reduced chemical background and endogenous interferences. The temperature control of the interface ensures excellent day-to-day reproducibility of the system.
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