QMS® Immunoassays for TDM

The two component assay system is based on the competitive inhibition immunoassay principle whereby free-drug in the sample competes for antibody binding sites with drug molecules coated onto uniform microparticles. The drug coated microparticle reagent is rapidly agglutinated in the presence of the antibody reagent and in the absence of any competing drug in the sample. The rate of absorbance change is measured photometrically and is proportional to the rate of agglutination of the microparticles. When a sample containing drug is added to the antibody reagent prior to the addition of the microparticle reagent, the agglutination reaction is inhibited by a degree that is directly related to the concentration of drug in the sample. A concentration-dependent classic agglutination inhibition curve can be obtained using QMS calibrators with the maximum rate of agglutination at the lowest drug concentration and the lowest agglutination rateat the highest drug concentration. Patient sample drug concentrations are determined from this standard curve. To learn more information about each assay, click on the spec sheets or product insert tabs located on the left.

QMS Benefits Include: Liquid stable and ready-to-use, applicable to general chemistry analyzers, validated parameters assure lab-to-lab reproducibility, superb reagent stabilit, excellent correlation t o reference methods, optimal sensitivity, precision and dynamic range, has low cross reactivity with metabolites and commonly co-administered drugs, low interference from endogenous substances and significantly reduces labor, time, and expense compared to HPLC or LCMS and other technologies.

FPIA Assays:  Click on the link if you are looking for our Innofluor assays which uses Fluorescence Polarization (FPIA). We hope to transition this product line www.thermo.comin the near future.