The
Ultra Cell - The Heart of the New FTICR
The Thermo Scientific LTQ FT Ultra mass spectrometer is the next
generation hybrid FTICR featuring a novel ICR cell design, the Ultra Cell. This
cell design produces enhanced sensitivity and greater dynamic range. The linear
excitation characteristics of the cell allow larger cyclotron radii which
significantly reduces space charge effects. These performance gains are
achieved without the costs and difficulties associated with a higher field
magnet.
- Attomole sensitivity
- Widest dynamic range ( > 4,000)
- ppb mass accuracy
- Resolution > 750,000
The new LTQ FT Ultra is built on the proven
Thermo Scientific linear ion trap and FTICR platform, featuring:
- Automatic Gain Control – concentration independent ppb
mass accuracy with space charge control
- Parrallel Acquisition – unmatched data dependant
acquisition speed
- ECD and IRMPD – detailed characterization of peptides
and proteins
- Fast Scan Rate with High Resolution – compatible with
LC timescale
- Automated Optimization and Acquisition – simplified
operation
ATTOMOLE
SENSITIVITY
For identification of low abundance peptides
50 attomole on column On-line nano-LC-MS/MS of a 5 protein mix digest
(50 attomole each on column, 30 min gradient). Data analysed with BioWorks 3.3.
All proteins found with at least 2 peptides, high Xcorr and high peptide
probability.
Maintain mass accuracy over a
WIDER
DYNAMIC RANGE
Concentration independent mass accuracy in infusion or under LC
conditions. Detect and correctly identify low abundant co-eluting species.
Single spectrum of a nano-LC-MS/MS run of a Yeast
Enolase digest
UNMATCHED
MASS ACCURACY
Eliminates false positive identifications in bottom-up proteomics.
Unambigous identification of unknown analytes with on-line LC-MS/MS at any
concentration.
Analysis of peptide MRFA, m/z 524
ULTRA
HIGH RESOLUTION
for analysis of complex mixtures
Ultra high resolution available on demand with a single mouse click.
Ultra high resolution is essential for the analysis of complex samples such as
crude oil or Disolved Organic Matter (DOM).
Measured versus simulated 2nd isotope peak of peptide
MRFA, at m/z 526.265
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