QuickQuan software was developed in partnership with multi-national pharmaceutical companies to provide a total solution for automated quantification in drug discovery. Combined with the Thermo Scientific TSQ Quantum™ triple quadrupole mass spectrometers, QuickQuan allows automated LC-MS/MS analysis of chemically diverse compounds.
QuickQuan simplifies automation required in the lead discovery and lead optimization environments. A multitude of chemically diverse compounds are analyzed and quantified in a completely automated manner using a TSQ Quantum mass spectrometer. The resultant LC-MS/MS data can then be used in a variety of ways to help drug compound assessment.
QuickQuan manages the data acquisition and processing for all compounds in the analytical run and generates quantitative results automatically. Data generated by QuickQuan is stored in a central Microsoft® Access or Oracle® database. This database allows fast and efficient retrieval of information about a specific compound and allows the compound to be used in multiple assays, eliminating the need to re-optimize the LC-MS/MS tune conditions.
QuickQuan provides:
Scalability
To meet future demands for increased capacity, QuickQuan’s ability to seamlessly drive the experiment from a central database enables “plug-and-play” installation of additional instruments.
Speed
Individual compounds can be fully auto-optimized in about one minute due to the infusion-based, valve switching auto-tuning procedure. This capability makes QuickQuan the fastest commercially available software solution for high-throughput LC-MS/MS.
Sensitivity
High sensitivity is achieved using Highly Selective Reaction Monitoring (H-SRM) and Heated Electrospray Ionization (H-ESI), enabling QuickQuan to successfully analyze a wide range of difficult-to-ionize compounds. In addition, new techniques such as Reversed Energy Ramp (RER) scanning used during the MS/MS analysis help to identify the optimal SRM transition. The use of breakdown curves enables an accurate determination of the optimum collision energy setting, ensuring the highest possible sensitivity for quantitation.
QuickQuan Ordering Options:
QuickQuan is available in three options: Software Only, QuickQuan Basic, and the fully-automated column switching option called the QuickQuan Total Solution.