Thermo Scientific modifying phosphoramidites are for the addition of a primary amine to the 5' position of an oligonucleotide or to incorporate an amine within the sequence.
The amino modification provides a site for attachment of fluorescent labels such as biotin or NuLight® esters. Oligos with an amino modification can also be attached to surfaces in DNA chip applications.
The 5' amino modifier amidites are supplied with MMT or TFA protection. The MMT modifier allows for trityl-on purification of the resulting oligonucleotide. The TFA group is removed during ammonia deprotection.
Thermo Scientific phosphorylating phosphoramidte is for the addition of a phosphate to the 5' or 3' position of the oligonucleotide during standard synthesis protocols.
Quality Control
Our controlled raw material supply chain and established vendor partnerships ensure consistency and security of supply. Processes are strictly controlled and monitored from material procurement through final QC and product release under ISO 9001 regulations. These validated processes provide batch to batch reproducibility creating consistent performance in oligonucleotide synthesis. All modifiers are supplied with lot-specific quality control data including HPLC and phosphorous NMR analyses.
Multi-Kilogram Lots
Versatile manufacturing facilities enable us to increase product throughput to meet increasing oligosynthesis needs. Products are available as multi-kilogram lots.
Flexible Packaging
Common pack sizes to fit most commercially available synthesizers are in stock and ready for immediate delivery. Custom and bulk packaging is also available for specific requirements.
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