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| LC-MS Application Notes: Solutions Index Page |
| To download or view application notes, please select one of the categories by name below or scroll down this page. |
Proteomics
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App Note 470: Streamlining the Process of Biomarker Verification using Pinpoint Software |
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Author(s): Scott M. Peterman1, Reiko Kiyonami1, Amol Prakash2, Mary Lopez2, Taha Rezai2, David Sarracino2, Bryan Krastins2, and Michael Athanas3, 1Thermo Fisher Scientific, San Jose, CA; 2Thermo Fisher Scientific BRIMS Center, Cambridge, MA; 3Vast Scientific, Wayland, MA
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App. Note 469: In-Depth, Comprehensive Mapping of the Human Seminal Plasma Proteome by a Novel, Iterative LC-MS/MS Analysis and Database Search Workflow |
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Author(s): Claire Dauly, Thermo Fisher Scientific, Courtaboeuf, France
Régis Lavigne, Charles Pineau, Proteomics Core Facility OUEST-genopole®, Inserm U625, Campus de Beaulieu, Rennes, France, Antoine D. Rolland, Inserm U625, Campus de Beaulieu, Rennes, France, Martin Hornshaw, Thermo Fisher Scientific, Hemel Hempstead, UK
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App. Note 459: Efficient Enrichment and Identification of Cell Lysate Phosphopeptides Using Magnetic Bead-Based System Coupled to High-Resolution LC/MS and SRM
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Author(s): Bryan Krastins, David Sarracino, J. Rogers, P. Haney, T. Rezai, Amol Prakash, Mary F. Lopez, Thermo Fisher Scientific, Waltham, MA, USA; Michael Athanas, VAST Scientific, Cambridge, MA, USA; J. Degnore, Tufts University, Boston, MA, USA
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App. Note 451: Absolute Quantitation of Targeted Endogenous Salivary Peptides using Heavy Isotope-labeled Internal Standards and High-Resolution Selective Reaction Monitoring Mass Spectrometry |
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Author(s): Markus Hardt, H. Ewa Witkowska, Steven C. Hall, Susan Fisher, University of California at San Francisco, San Francisco, CA, USA; Reiko Kiyonami, Rosa Viner, Vlad Zabrouskov, Thermo Fisher Scientific, San Jose, CA, USA
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App. Note 444: A Robust and Sensitive Workflow for Label-Free, Quantitative Identification of Differentially Expressed, Endogenous Peptides in Human Serum |
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Author(s): David Sarracino, Bryan Krastins, Amol Prakash, Mary F. Lopez, Thermo Fisher Scientific BRIMS Center, Cambridge, MA, USA; Michael Athanas, Vast Scientific, Cambridge, MA, USA; Ramesh Kuppasamy, Kypros Nicolaides, Fetal Medicine Foundation, London, UK
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App. Note 443: Quantitative Proteomic Workflow for Discovery of Early Rejection Kidney Transplant Peptide Biomarkers and Subsequent Development of SRM Assays in Urine |
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Author(s): David Sarracino, Bryan Krastins, Amol Prakash, Mary F Lopez, Thermo Fisher Scientific BRIMS Center, Cambridge, MA, USA; Waichi Wong, Emmanuel Zorn, Massachusetts General Hospital, Harvard, Boston, MA, USA; Michael Athanas, Vast Scientific, Cambridge, MA, USA
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App. Note 360: Increased Coverage in the Transmembrane Domain with Activated Ion ECD for Top-down FTMS of Integral Membrane Proteins |
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| Author(s): Vlad Zabrouskov,1 Jennifer Zhang,1 Thomas D. McClure,1 Julian P.Whitelegge2, 1Thermo Fisher Scientific, San Jose, California, USA; 2The Pasarow Mass Spectrometry Laboratory, The Departments of Psychiatry and Biobehavioral Sciences, Chemistry and Biochemistry and The Jane & Terry Semel Institute for Neuroscience and Human Behavior, The Molecular Biology Institute and The Brain Research Institute, UCLA, Los Angeles, California, USA |
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App. Note 345: Proteomics in ADME Tox Studies: High-Throughput Identification and ESI Linear Ion Trap Mass Spectrometry with 2D-DIGE |
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| Author(s): Ola Rönn1, Johan Öhman1, Daniel Haid1, Helena Nordvarg1, Lena Hörnsten1, John Flensburg1, Erik Forsberg1, David Fenyö1,Hélèn Bergling1, Gary Woffendin2, and Michaela Scigelova2 (1GE Healthcare, Uppsala, Sweden; 2Thermo Fisher Scientific, Hemel Hempstead, UK) |
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App. Note 344: Top-Down Analysis of the Low Molecular Weight Human Plasma Proteome Using Hybrid Ion Trap-Fourier Transform Mass Spectrometry |
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| Author(s): Jennifer N. Sutton1,5 , Leo E. Bonilla1, Tori Richmond1, Robert E. Gerszten2, Emerson Liu2, Xui Shi2, Michael Senko3, Vladimir Zabrouskov3, Neil L. Kelleher4, Andrew Forbes4, Robert G. Harper5 (1Biomarker Research Initiatives in Mass Spectrometry (BRIMS) Center, Thermo Fisher Scientific, Boston, MA; 2Cardiology Division and Center for Immunology & Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, MA; 3Thermo Fisher Scientific, San Jose, CA; 4Center forTop Down Proteomics, Department of Chemistry, University of Illinois, Urbana, IL; 5Department of Chemistry,WestVirginia University, Morgantown,WV) |
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App. Note 343: Identification and Differential Expression Analysis of Putative and Known Plasma Biomarkers for Human Hypertrophic Cardiomyopathy |
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Author(s): Tori Richmond1, Manor Askenazi1, Leo Bonilla1, Robert E. Gerszten2, Jennifer Sutton1, Emerson Liu2, David Sarracino3 (1Biomarker Research Initiatives in Mass Spectrometry (BRIMS) Center, Thermo Fisher Scientific, Boston, MA; 2Cardiology Division and Center for Immunology & Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, MA; 3Harvard-Partners Center for Genetics and Genomics, Cambridge, MA)
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App. Note 430: Identification of GSH Conjugates Using Accurate Mass Data and MetWorks Software |
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Author(s): Amber Kohl , Thermo Fisher Scientific, West Palm Beach, FL, USA; Heng-Keang Lim , Johnson and Johnson Pharmaceutical Research Institute, Raritan, NJ, USA; Yingying Huang , Thermo Fisher Scientific, San Jose, CA, USA
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App. note 422: Distribution of Irinotecan in Liver and a HumanTumor Xenograft Model by Tissue Imaging Mass Spectrometry |
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Author(s): Maria C. Prieto Conaway1, Shousong Cao2, Farukh Durrani2, Youcef Rustum2, Ping Wang3, Khin Marlar3, Latif Kazim3; 1 Thermo Fisher Scientific, San Jose, CA, USA; 2Roswell Park Cancer Institute, Dept. of Cancer Biology, Buffalo, NY, USA; 3 Roswell Park Cancer Institute, Dept. of Cell Stress Biology, Buffalo, NY, USA
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App. note 415 Experimental Strategies for Determining the Distribution of Erlotinib in Pancreatic Tumors by MALDI Using an LTQ Linear Ion Trap Mass Spectrometer |
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Author(s): M.C. Prieto Conaway1, H. Bui1, S. Beachy2, R. Pitoniak2, B. Hylander2, P.Wang2, K. Marlar2, E. Repasky2, L. Kazim2, 1Thermo Fisher Scientific, San Jose, CA, USA; 2Roswell Park Cancer Institute, Buffalo, NY, USA
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App. Note 406: Study of Free Radical Fragment Ions Generated from ESI-CID-MS/MS Using LTQ and LTQ Orbitrap Mass Spectrometers |
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| Author(s): Guifen Xu1, Tom Huang1, Jennifer Zhang2, Thomas D. McClure2, and Shichang Miao1 * 1 PKDM Department, Amgen SSF, South San Francisco, CA USA; *Analytical Chemistry and DMPK, ChemoCentryx Inc., Mountain View, CA USA; 2Thermo Fisher Scientific, San Jose, CA USA |
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App. note 413: The Distribution of Metabolites of Di-(2-ethylhexyl) Phthalate on a Whole Rat by Imaging MS Using a MALDI Ion Trap |
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Author(s): T.A. Snow,1 M.Prieto Conaway,2 H. Bui,2 W.J.Fasano,1 L.A. Manning1, 1DuPont Haskell Laboratory, Newark, DE, USA; 2Thermo Fisher Scientific, San Jose, CA, USA
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App. Note 345: Proteomics in ADME Tox Studies: High-Throughput Identification and ESI Linear Ion Trap Mass Spectrometry with 2D-DIGE |
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| Author(s): Ola Rönn1, Johan Öhman1, Daniel Haid1, Helena Nordvarg1, Lena Hörnsten1, John Flensburg1, Erik Forsberg1, David Fenyö1,Hélèn Bergling1, Gary Woffendin2, and Michaela Scigelova2 (1GE Healthcare, Uppsala, Sweden; 2Thermo Fisher Scientific, Hemel Hempstead, UK) |
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App. Note 343: Identification and Differential Expression Analysis of Putative and Known Plasma Biomarkers for Human Hypertrophic Cardiomyopathy |
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Author(s): Tori Richmond1, Manor Askenazi1, Leo Bonilla1, Robert E. Gerszten2, Jennifer Sutton1, Emerson Liu2, David Sarracino3 (1Biomarker Research Initiatives in Mass Spectrometry (BRIMS) Center, Thermo Fisher Scientific, Boston, MA; 2Cardiology Division and Center for Immunology & Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, MA; 3Harvard-Partners Center for Genetics and Genomics, Cambridge, MA)
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App. note 466: Detection of Pharmaceuticals, Personal Care Products, and Pesticides in Water Resources by APCI-LC-MS/MS |
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Author(s): Liza Viglino1, Khadija Aboulfald1, Michèle Prévost2, and Sébastien Sauvé1; 1Department of Chemistry, Université de Montréal, Montréal, QC, Canada; 2Département of Civil, Geological, and Mining Engineering, École Polytechnique de Montréal, Montréal, QC, Canada
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App. Note 30173: Direct Analysis of Red Wine Using Ultra-Fast Chromatography and High Resolution Mass Spectrometry |
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| Author(s): Eugen Damoc, Michaela Scigelova, Anastassios E. Giannakopulos, Thomas Moehring, Thermo Fisher Scientific, Hanna-Kunath-Str. 11, 28199 Bremen, Germany; Frantisek Pehal, NNH Hospital Na Homolce, Roentgenova 2, 150 30 Prague, Czech Republic; Martin Hornshaw, Thermo Fisher Scientific, 1 Boundary Park, Hemel Hempstead HP2 7GE, UK |
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App Note 30163: High Resolution and Precise Mass Accuracy A Perfect Combination for Food and Feed Analysis in Complex Matrices |
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| Author(s): Markus Kellmann, Andreas Wieghaus, Helmut Muenster, Thermo Fisher Scientific, Bremen, Germany; Lester Taylor, Dipankar Ghosh, Germany, Thermo Fisher Scientific, San Jose, CA, USA |
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App. Note 387: Multi-residue Analysis of Pesticides in Food Using GC/MS/MS with the TSQ Quantum GC |
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Author(s): Kuniyo Sugitate, Michiko Kanai, Thermo Fisher Scientific, Yokohama, Japan, Masahiro Okihashi, Division of Food Chemistry, Osaka Prefectural Institute of Public Health, Osaka, Japan, Dipankar Ghosh, Thermo Fisher Scientific, San Jose, CA, USA
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App. Note 372: LC/MS/MS Analysis of Anti-Infectives In Raw and Treated Sewage |
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| Author(s): P.A. Segura1, A. Garcia Ac1, A. Lajeunesse2, D. Ghosh3, C. Gagnon2 and S. Sauvé1, 1 Département de Chimie, Université de Montréal, C.P. 6128, succursale Centre-ville, Montréal, QC, Canada H3C 3J7, 2 Centre Saint-Laurent, Environnement Canada, 105, rue McGill, Montréal, QC, Canada H2Y 2E7, 3 Thermo Fisher Scientific, San Jose, CA, USA |
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App. Note 436: Bioanalytical Assay for Neurotransmitters in Whole Blood by LC-MS/MS |
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Author(s): Yang Shi, Catherine Lafontaine, Francois A. Espourteille , Thermo Fisher Scientific, Franklin, MA, USA , Thermo Fisher Scientific, Franklin, MA, USA
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App. note 422: Distribution of Irinotecan in Liver and a HumanTumor Xenograft Model by Tissue Imaging Mass Spectrometry |
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Author(s): Maria C. Prieto Conaway1, Shousong Cao2, Farukh Durrani2, Youcef Rustum2, Ping Wang3, Khin Marlar3, Latif Kazim3; 1Thermo Fisher Scientific, San Jose, CA, USA; 2Roswell Park Cancer Institute, Dept. of Cancer Biology, Buffalo, NY, USA; 3Roswell Park Cancer Institute, Dept. of Cell Stress Biology, Buffalo, NY, USA
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App. Note 349: Measurement of Metabolic Stability Using SIM and Identification of Metabolites by Data Dependent Full-Scan MS/MS and CNL Scanning |
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| Author(s): Peter B Ehmer, Ethirajulu Kantharaj, Katie De Wagter, Anne Van Vlaslaer, Claire Mackie and Ron AHJ Gilissen; Department of ADME/Tox, In Vitro Pharmacokinetics Group, Johnson & Johnson Pharmaceutical Research & Development, 2340 Beerse, Belgium; Dipankar Ghosh and Karel Lazou; Thermo Fisher Scientific, San Jose, CA, USA |
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App. Note 314: Fast Quantitative Analysis of Pergolide Using APCI on the TSQ Quantum Discovery |
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Author(s): Nicola Hughes,1 Antony Harvey,2 Witold Winnik,3 and Gary Paul3 (1Biovail Contract Research, Toronto, Ontario, Canada; 2Thermo Fisher Scientific, San Jose, CA, USA; 3Thermo Fisher Scientific, Somerset, NJ, USA)
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App. Note 310: Improved Quantitative Selectivity of Clenbuterol in Human Urine Using High Resolution on the TSQ Quantum Mass Spectrometer |
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Author(s): Mark Churchill1, Mark Harrison1, John Henninge,2 and Hanne Lund2 (1Thermo Fisher Scientific, Stafford House, 1 Boundary Park, Boundary Way, Hemel Hempstead, HP2 7GE, UK; 2Aker University Hospital, Hormone Laboratory, Section for Doping Analysis, Trondheimsveien, N-0514, Oslo, Norway)
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App. Note 309: Quantitation of Cabergoline at Extremely Low Plasma Concentrations with a Triple Quadrupole Mass Spectrometer |
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Author(s): Nicola Hughes,1 Antony Harvey,2 Witold Winnik,3 Jean-Jacque Dunyach,2 Ma’an Amad,2 Maurizio Splendore,2 and Gary Paul3(1Biovail Contract Research, Toronto, Ontario, Canada;2Thermo Fisher Scientific, San Jose, CA, USA; 3Thermo Fisher Scientific, Somerset, NJ, USA Systemic Plasma Analysis)
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App. Note 467: Screening Drugs and Toxic Compounds with LC-MS/MS: An Alternative to LC-UV for Research Toxicology Labs |
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Author(s): Jordan Velardo1, Monique Manchon1, Bénédicte Duretz2, Dennis Nagtalon3, Marta Kozak3;1Laboratory of Toxicology, Lyon Sud Hospital, Pierre-Bénite, France; 2Thermo Fisher Scientific, Les Ulis, France; 3Thermo Fisher Scientific, San Jose, CA, USA
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App. Note 436: Bioanalytical Assay for Neurotransmitters in Whole Blood by LC-MS/MS |
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Author(s): Yang Shi, Catherine Lafontaine, Francois A. Espourteille , Thermo Fisher Scientific, Franklin, MA, USA , Thermo Fisher Scientific, Franklin, MA, USA
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App. Note 429: Quantitative Analysis of Testosterone in Serum by LC-MS/MS |
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Author(s): Ravinder J. Singh, Ph.D., James L. Bruton, Mayo Clinic, Rochester, MN, USA; Taha Rezai, Ph.D., Thermo Fisher Scientific, San Jose, CA, USA
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App. Note 30173: Direct Analysis of Red Wine Using Ultra-Fast Chromatography and High Resolution Mass Spectrometry |
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| Author(s): Eugen Damoc, Michaela Scigelova, Anastassios E. Giannakopulos, Thomas Moehring, Thermo Fisher Scientific, Hanna-Kunath-Str. 11, 28199 Bremen, Germany; Frantisek Pehal, NNH Hospital Na Homolce, Roentgenova 2, 150 30 Prague, Czech Republic; Martin Hornshaw, Thermo Fisher Scientific, 1 Boundary Park, Hemel Hempstead HP2 7GE, UK |
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App. note 422: Distribution of Irinotecan in Liver and a HumanTumor Xenograft Model by Tissue Imaging Mass Spectrometry |
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Author(s): Maria C. Prieto Conaway1, Shousong Cao2, Farukh Durrani2, Youcef Rustum2, Ping Wang3, Khin Marlar3, Latif Kazim3; 1 Thermo Fisher Scientific, San Jose, CA, USA; 2Roswell Park Cancer Institute, Dept. of Cancer Biology, Buffalo, NY, USA; 3 Roswell Park Cancer Institute, Dept. of Cell Stress Biology, Buffalo, NY, USA
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App. note 418: Re-interrogation of Verapamil Metabolites in Bile Using Time-based Data-dependent Mass Lists and a Mass Defect Filter with the LTQ Orbitrap |
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Author(s): Laurance L. Lee1, Yan Chen1, Ji Ma2, Robert Cho2, Hoa Le2, Theresa McLaughlin3, and Shichang Miao4, 1Thermo Fisher Scientific, San Jose, CA; 2Amgen, South San Francisco, CA; 3Current Affiliation: Stanford University, Stanford, CA; 4Current Affiliation: Chemocentryx, Inc., Mountain View, CA
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App. note 417: Using Multiple Mass Defect Filters and Higher Energy Collisional Dissociation on an LTQ Orbitrap XL for Fast, Sensitive and Accurate Metabolite ID |
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Author(s): Yingying Huang1, Shirley Liu2, Shichang Miao2, Patrick M. Jeanville1, 1Thermo Fisher Scientific, San Jose, CA, USA; 2ChemoCentryx, Mountain View, CA, USA
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App. Note 406: Study of Free Radical Fragment Ions Generated from ESI-CID-MS/MS Using LTQ and LTQ Orbitrap Mass Spectrometers |
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| Author(s): Guifen Xu1, Tom Huang1, Jennifer Zhang2, Thomas D. McClure2, and Shichang Miao1 * 1 PKDM Department, Amgen SSF, South San Francisco, CA USA; *Analytical Chemistry and DMPK, ChemoCentryx Inc., Mountain View, CA USA; 2Thermo Fisher Scientific, San Jose, CA USA |
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App. note 415 Experimental Strategies for Determining the Distribution of Erlotinib in Pancreatic Tumors by MALDI Using an LTQ Linear Ion Trap Mass Spectrometer |
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Author(s): M.C. Prieto Conaway1, H. Bui1, S. Beachy2, R. Pitoniak2, B. Hylander2, P.Wang2, K. Marlar2, E. Repasky2, L. Kazim2, 1Thermo Fisher Scientific, San Jose, CA, USA; 2Roswell Park Cancer Institute, Buffalo, NY, USA
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App. note 413: The Distribution of Metabolites of Di-(2-ethylhexyl) Phthalate on a Whole Rat by Imaging MS Using a MALDI Ion Trap |
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Author(s): T.A. Snow,1 M.Prieto Conaway,2 H. Bui,2 W.J.Fasano,1 L.A. Manning1, 1DuPont Haskell Laboratory, Newark, DE, USA; 2Thermo Fisher Scientific, San Jose, CA, USA
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App. Note 392: Profiling and Characterization of Polyphenol Polymers from Cinnamon Using an Ion Trap Mass Spectrometer |
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| Author(s): Min He1, Peter Wang2, Ying Xiang3, Ying Qi3, Howard Sun3, and Julian Phillips1, 1Thermo Fisher Scientific, San Jose, CA, USA; 2Thermo Fisher Scientific, Shanghai, China; 3Shanghai R&D, Nu Sin Enterprises, Shanghai, China |
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App. Note 367: Essential Lipidomics Experiments Using the LTQ Orbitrap Hybrid Mass Spectrometer |
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| Author(s): Thomas Moehring1, Michaela Scigelova2, Christer S. Ejsing3, Dominik Schwudke3, Andrej Shevchenko3 1Thermo Fisher Scientific, Bremen, Germany; 2Thermo Fisher Scientific, Hemel Hempstead, UK; 3Max-Planck-Institute of Molecular Cell Biology and Genetics, Dresden, Germany |
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App. Note 359: Determination of Direct Glucuronidation of NCEs in Liver Microsomes Using SIM, Data Dependent Full-Scan MS/MS and CNL Scanning. |
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| Author(s): Veronique Van Genechten, Ethirajulu Kantharaj, Peter B Ehmer, Claire Mackie and Ron AHJ Gilissen; Department of ADME/Tox, In Vitro Pharmacokinetics Group, Johnson & Johnson Pharmaceutical Research & Development, 2340 Beerse, Belgium; Dipankar Ghosh, Louis Maljers and Karel Lazou; Thermo Fisher Scientific, San Jose, CA, USA |
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App. Note 349: Measurement of Metabolic Stability Using SIM and Identification of Metabolites by Data Dependent Full-Scan MS/MS and CNL Scanning |
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| Author(s): Peter B Ehmer, Ethirajulu Kantharaj, Katie De Wagter, Anne Van Vlaslaer, Claire Mackie and Ron AHJ Gilissen; Department of ADME/Tox, In Vitro Pharmacokinetics Group, Johnson & Johnson Pharmaceutical Research & Development, 2340 Beerse, Belgium; Dipankar Ghosh and Karel Lazou; Thermo Fisher Scientific, San Jose, CA, USA |
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