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| LC-MS Application Notes: Solutions Index Page |
| To download or view application notes, please select one of the categories by name below or scroll down this page. |
Proteomics
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App. Note 360: Increased Coverage in the Transmembrane Domain with Activated Ion ECD for Top-down FTMS of Integral Membrane Proteins |
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| Author(s): Vlad Zabrouskov,1 Jennifer Zhang,1 Thomas D. McClure,1 Julian P.Whitelegge2, 1Thermo Fisher Scientific, San Jose, California, USA; 2The Pasarow Mass Spectrometry Laboratory, The Departments of Psychiatry and Biobehavioral Sciences, Chemistry and Biochemistry and The Jane & Terry Semel Institute for Neuroscience and Human Behavior, The Molecular Biology Institute and The Brain Research Institute, UCLA, Los Angeles, California, USA |
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App. Note 345: Proteomics in ADME Tox Studies: High-Throughput Identification and ESI Linear Ion Trap Mass Spectrometry with 2D-DIGE |
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| Author(s): Ola Rönn1, Johan Öhman1, Daniel Haid1, Helena Nordvarg1, Lena Hörnsten1, John Flensburg1, Erik Forsberg1, David Fenyö1,Hélèn Bergling1, Gary Woffendin2, and Michaela Scigelova2 (1GE Healthcare, Uppsala, Sweden; 2Thermo Fisher Scientific, Hemel Hempstead, UK) |
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App. Note 344: Top-Down Analysis of the Low Molecular Weight Human Plasma Proteome Using Hybrid Ion Trap-Fourier Transform Mass Spectrometry |
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| Author(s): Jennifer N. Sutton1,5 , Leo E. Bonilla1, Tori Richmond1, Robert E. Gerszten2, Emerson Liu2, Xui Shi2, Michael Senko3, Vladimir Zabrouskov3, Neil L. Kelleher4, Andrew Forbes4, Robert G. Harper5 (1Biomarker Research Initiatives in Mass Spectrometry (BRIMS) Center, Thermo Fisher Scientific, Boston, MA; 2Cardiology Division and Center for Immunology & Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, MA; 3Thermo Fisher Scientific, San Jose, CA; 4Center forTop Down Proteomics, Department of Chemistry, University of Illinois, Urbana, IL; 5Department of Chemistry,WestVirginia University, Morgantown,WV) |
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App. note 415 Experimental Strategies for Determining the Distribution of Erlotinib in Pancreatic Tumors by MALDI Using an LTQ Linear Ion Trap Mass Spectrometer |
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Author(s): M.C. Prieto Conaway1, H. Bui1, S. Beachy2, R. Pitoniak2, B. Hylander2, P.Wang2, K. Marlar2, E. Repasky2, L. Kazim2, 1Thermo Fisher Scientific, San Jose, CA, USA; 2Roswell Park Cancer Institute, Buffalo, NY, USA
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App. Note 406: Study of Free Radical Fragment Ions Generated from ESI-CID-MS/MS Using LTQ and LTQ Orbitrap Mass Spectrometers |
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| Author(s): Guifen Xu1, Tom Huang1, Jennifer Zhang2, Thomas D. McClure2, and Shichang Miao1 * 1 PKDM Department, Amgen SSF, South San Francisco, CA USA; *Analytical Chemistry and DMPK, ChemoCentryx Inc., Mountain View, CA USA; 2Thermo Fisher Scientific, San Jose, CA USA |
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App. note 413: The Distribution of Metabolites of Di-(2-ethylhexyl) Phthalate on a Whole Rat by Imaging MS Using a MALDI Ion Trap |
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Author(s): T.A. Snow,1 M.Prieto Conaway,2 H. Bui,2 W.J.Fasano,1 L.A. Manning1, 1DuPont Haskell Laboratory, Newark, DE, USA; 2Thermo Fisher Scientific, San Jose, CA, USA
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App. Note 345: Proteomics in ADME Tox Studies: High-Throughput Identification and ESI Linear Ion Trap Mass Spectrometry with 2D-DIGE |
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| Author(s): Ola Rönn1, Johan Öhman1, Daniel Haid1, Helena Nordvarg1, Lena Hörnsten1, John Flensburg1, Erik Forsberg1, David Fenyö1,Hélèn Bergling1, Gary Woffendin2, and Michaela Scigelova2 (1GE Healthcare, Uppsala, Sweden; 2Thermo Fisher Scientific, Hemel Hempstead, UK) |
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App. Note 343: Identification and Differential Expression Analysis of Putative and Known Plasma Biomarkers for Human Hypertrophic Cardiomyopathy |
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Author(s): Tori Richmond1, Manor Askenazi1, Leo Bonilla1, Robert E. Gerszten2, Jennifer Sutton1, Emerson Liu2, David Sarracino3 (1Biomarker Research Initiatives in Mass Spectrometry (BRIMS) Center, Thermo Fisher Scientific, Boston, MA; 2Cardiology Division and Center for Immunology & Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, MA; 3Harvard-Partners Center for Genetics and Genomics, Cambridge, MA)
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App. Note 387: Multi-residue Analysis of Pesticides in Food Using GC/MS/MS with the TSQ Quantum GC |
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Author(s): Kuniyo Sugitate, Michiko Kanai, Thermo Fisher Scientific, Yokohama, Japan, Masahiro Okihashi, Division of Food Chemistry, Osaka Prefectural Institute of Public Health, Osaka, Japan, Dipankar Ghosh, Thermo Fisher Scientific, San Jose, CA, USA
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App. Note 372: LC/MS/MS Analysis of Anti-Infectives In Raw and Treated Sewage |
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| Author(s): P.A. Segura1, A. Garcia Ac1, A. Lajeunesse2, D. Ghosh3, C. Gagnon2 and S. Sauvé1, 1 Département de Chimie, Université de Montréal, C.P. 6128, succursale Centre-ville, Montréal, QC, Canada H3C 3J7, 2 Centre Saint-Laurent, Environnement Canada, 105, rue McGill, Montréal, QC, Canada H2Y 2E7, 3 Thermo Fisher Scientific, San Jose, CA, USA |
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App. Note 349: Measurement of Metabolic Stability Using SIM and Identification of Metabolites by Data Dependent Full-Scan MS/MS and CNL Scanning |
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| Author(s): Peter B Ehmer, Ethirajulu Kantharaj, Katie De Wagter, Anne Van Vlaslaer, Claire Mackie and Ron AHJ Gilissen; Department of ADME/Tox, In Vitro Pharmacokinetics Group, Johnson & Johnson Pharmaceutical Research & Development, 2340 Beerse, Belgium; Dipankar Ghosh and Karel Lazou; Thermo Fisher Scientific, San Jose, CA, USA |
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App. Note 314: Fast Quantitative Analysis of Pergolide Using APCI on the TSQ Quantum Discovery |
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Author(s): Nicola Hughes,1 Antony Harvey,2 Witold Winnik,3 and Gary Paul3 (1Biovail Contract Research, Toronto, Ontario, Canada; 2Thermo Fisher Scientific, San Jose, CA, USA; 3Thermo Fisher Scientific, Somerset, NJ, USA)
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App. Note 310: Improved Quantitative Selectivity of Clenbuterol in Human Urine Using High Resolution on the TSQ Quantum Mass Spectrometer |
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Author(s): Mark Churchill1, Mark Harrison1, John Henninge,2 and Hanne Lund2 (1Thermo Fisher Scientific, Stafford House, 1 Boundary Park, Boundary Way, Hemel Hempstead, HP2 7GE, UK; 2Aker University Hospital, Hormone Laboratory, Section for Doping Analysis, Trondheimsveien, N-0514, Oslo, Norway)
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App. Note 309: Quantitation of Cabergoline at Extremely Low Plasma Concentrations with a Triple Quadrupole Mass Spectrometer |
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Author(s): Nicola Hughes,1 Antony Harvey,2 Witold Winnik,3 Jean-Jacque Dunyach,2 Ma’an Amad,2 Maurizio Splendore,2 and Gary Paul3(1Biovail Contract Research, Toronto, Ontario, Canada;2Thermo Fisher Scientific, San Jose, CA, USA; 3Thermo Fisher Scientific, Somerset, NJ, USA Systemic Plasma Analysis)
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