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  LC-MS Application Notes: LTQ Orbitrap, LTQ FT, LTQ and LXQ Instrument Index Page
 To download or view LTQ Orbitrap, LTQ FT, LTQ and LXQ applications notes, select one of the categories by name below or scroll down this page.
 

Exactive

  App Note 30163: High Resolution and Precise Mass Accuracy A Perfect Combination for Food and Feed Analysis in Complex Matrices
 
Author(s): Markus Kellmann, Andreas Wieghaus, Helmut Muenster, Thermo Fisher Scientific, Bremen, Germany; Lester Taylor, Dipankar Ghosh, Germany, Thermo Fisher Scientific, San Jose, CA, USA
 

 

  App. note 30162: The Thermo Scientific Exactive Benchtop LC/MS Orbitrap Mass Spectrometer
 
 
Author(s): Andreas Wieghaus, Alexander Makarov, Ulf Froehlich, Markus Kellmann, Eduard Denisov, Oliver Lange, Thermo Fisher Scientific, Bremen, Germany
 

 

LTQ Orbitrap

App. Note 30173: Direct Analysis of Red Wine Using Ultra-Fast Chromatography and High Resolution Mass Spectrometry   App. Note 30173: Direct Analysis of Red Wine Using Ultra-Fast Chromatography and High Resolution Mass Spectrometry
 
Author(s): Eugen Damoc, Michaela Scigelova, Anastassios E. Giannakopulos, Thomas Moehring, Thermo Fisher Scientific, Hanna-Kunath-Str. 11, 28199 Bremen, Germany; Frantisek Pehal, NNH Hospital Na Homolce, Roentgenova 2, 150 30 Prague, Czech Republic; Martin Hornshaw, Thermo Fisher Scientific, 1 Boundary Park, Hemel Hempstead HP2 7GE, UK 
 

App. Note 450: Analysis of Mitotic Phosphorylation Sites in the Nuclear Pore Complex Using a MALDI LTQ Orbitrap Mass Spectrometer    App. Note 450: Analysis of Mitotic Phosphorylation Sites in the Nuclear Pore Complex Using a MALDI LTQ Orbitrap Mass Spectrometer
 
 

Author(s): Justin Blethrow1, Rosa Viner1, Vlad Zabrouskov1, and Joseph Glavy2; 1 Thermo Fisher Scientific, San Jose, CA; 2Stevens Institute of Technology, Hoboken, NJ

 
 

App. Note 445: Quantitative Profiling of DNA Damage Response Proteins Using iTRAQ Labeling and LTQ Orbitrap XL   App. Note 445: Quantitative Profiling of DNA Damage Response Proteins Using iTRAQ Labeling and LTQ Orbitrap XL
 
 

Author(s): Rosa Viner,1 Ryan Bomgarden,2 Terry Zhang,1 Michael Major,2 and Vlad Zabrouskov1; Thermo Fisher Scientific, San Jose, CA; 2Thermo Fisher Scientific, Rockford, IL

 

 
 

App. note 430: Identification of GSH Conjugates Using Accurate Mass Data and MetWorks Software   App. Note 430: Identification of GSH Conjugates Using Accurate Mass Data and MetWorks Software
 
 

Author(s): Amber Kohl, Thermo Fisher Scientific, West Palm Beach, FL, USA;Heng-Keang Lim, Johnson and Johnson Pharmaceutical Research Institute, Raritan, NJ, USA;Yingying Huang, Thermo Fisher Scientific, San Jose, CA, USA


 

 
 

App. note 418: Re-interrogation of Verapamil Metabolites in Bile Using Time-based   App. note 418: Re-interrogation of Verapamil Metabolites in Bile Using Time-based Data-dependent Mass Lists and a Mass Defect Filter with the LTQ Orbitrap
 
 

Author(s): Laurance L. Lee1, Yan Chen1, Ji Ma2, Robert Cho2, Hoa Le2, Theresa McLaughlin3, and Shichang Miao4, 1Thermo Fisher Scientific, San Jose, CA; 2Amgen, South San Francisco, CA; 3Current Affiliation: Stanford University, Stanford, CA; 4Current Affiliation: Chemocentryx, Inc., Mountain View, CA


 

 
 

App. note 417: Using Multiple Mass Defect Filters and Higher Energy Collisional   App. note 417: Using Multiple Mass Defect Filters and Higher Energy Collisional Dissociation on an LTQ Orbitrap XL for Fast, Sensitive and Accurate Metabolite ID
 
 

Author(s): Yingying Huang1, Shirley Liu2, Shichang Miao2, Patrick M. Jeanville1, 1 Thermo Fisher Scientific, San Jose, CA, USA; 2ChemoCentryx, Mountain View, CA, USA

 
 

 
  App. Note 406: Study of Free Radical Fragment Ions Generated from ESI-CID-MS/MS Using LTQ and LTQ Orbitrap Mass Spectrometers
 
 
Author(s):  Guifen Xu1, Tom Huang1, Jennifer Zhang2, Thomas D. McClure2, and Shichang Miao1 * 1 PKDM Department, Amgen SSF, South San Francisco, CA USA; *Analytical Chemistry and DMPK, ChemoCentryx Inc., Mountain View, CA USA; 2Thermo Fisher Scientific, San Jose, CA USA
 
 

  App. Note 386: Advantages of the LTQ Orbitrap for Protein Identification in Complex Digests
 
 

Author(s): Rosa Viner, Terry Zhang, Scott Peterman, and Vlad Zabrouskov, Thermo Fisher Scientific, San Jose, CA, USA

 
 

 
  App. Note 367: Essential Lipidomics Experiments Using the LTQ Orbitrap Hybrid Mass Spectrometer
 
 
Author(s): Thomas Moehring1, Michaela Scigelova2, Christer S. Ejsing3, Dominik Schwudke3, Andrej Shevchenko3 1Thermo Fisher Scientific, Bremen, Germany; 2Thermo Fisher Scientific, Hemel Hempstead, UK; 3Max-Planck-Institute of Molecular Cell Biology and Genetics, Dresden, Germany      
 
 

 

LTQ FT

  App. Note 30121 Elemental Composition Determination
 
 
Author(s): Martin Zeller, Wolfgang Metelmann-Strupat, Markus Kellmann and Bernard Delanghe, Thermo Fisher Scientific, Bremen, Germany; Scott Peterman, Thermo Fisher Scientific, Somerset, NJ, USA
 
 

 
  App. Note 369: A High Throughput Approach for Metabolite Profiling and Characterization Using the LXQ Linear Ion Trap Mass Spectrometer
 
 
Author(s): Min He, Alicia Du, Gargi Choudhary, Karen Salomon and Diane Cho; Thermo Fisher Scientific, San Jose, CA, USA
 
 

  App. Note 368: Single Ion Monitoring with 0.5 ppm Mass Accuracy Coupled with Data Dependent Decisions in Complex LC-MS/MS Runs
 
 
Author(s): Thomas Moehring, Kerstin Strupat, Martin Zeller, Wolfgang Metelmann-Strupat, Bernard Delanghe; Thermo Fisher Scientific
 
 

  App. Note 365: Top-Down Analysis of Intact Proteins by Electron Capture Dissociation (ECD)
 
 
Author(s): Jennifer Zhang, Vlad Zabrouskov, and Thomas D. McClure; Thermo Fisher Scientific, San Jose, CA
 
 

  App. Note 360: Increased Coverage in the Transmembrane Domain with Activated Ion ECD for Top-down FTMS of Integral Membrane Proteins.
 
 
Author(s): Vlad Zabrouskov,1 Jennifer Zhang,1 Tom D. McClure,1 Julian P.Whitelegge2, 1Thermo Scientific, San Jose, California, USA; 2The Pasarow Mass Spectrometry Laboratory, The Departments of Psychiatry and Biobehavioral Sciences, Chemistry and Biochemistry and The Jane & Terry Semel Institute for Neuroscience and Human Behavior, The Molecular Biology Institute and The Brain Research Institute, UCLA, Los Angeles, California, USA
 
 

  App. Note 344: Top-Down Analysis of the Low Molecular Weight Human Plasma Proteome Using Hybrid Ion Trap-Fourier Transform Mass Spectrometry.
   
Author(s):  Jennifer N. Sutton1,5 , Leo E. Bonilla1, Tori Richmond1, Robert E. Gerszten2, Emerson Liu2, Xui Shi2, Michael Senko3, Vladimir Zabrouskov3, Neil L. Kelleher4, Andrew Forbes4, Robert G. Harper5 (1Biomarker Research Initiatives in Mass Spectrometry (BRIMS) Center, Thermo Fisher Scientific, Boston, MA; 2Cardiology Division and Center for Immunology & Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, MA; 3Thermo Fisher Scientific, San Jose, CA; 4Center forTop Down Proteomics, Department of Chemistry, University of Illinois, Urbana, IL; 5Department of Chemistry,WestVirginia University, Morgantown,WV)

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LTQ XL

App. Note 452: Relative Quantitation of Protein Digests Using Tandem Mass Tags and Pulsed-Q Dissociation (PQD)   App. Note 452: Relative Quantitation of Protein Digests Using Tandem Mass Tags and Pulsed-Q Dissociation (PQD)
 
 

Author(s): Jae Schwartz, Terry Zhang, Rosa Viner, Vlad Zabrouskov, Thermo Fisher Scientific, San Jose, CA, USA

 
 

App. note 422: Distribution of Irinotecan in Liver and a HumanTumor Xenograft Model by Tissue Imaging Mass Spectrometry   App. note 422: Distribution of Irinotecan in Liver and a HumanTumor Xenograft Model by Tissue Imaging Mass Spectrometry 
 
 

Author(s): Maria C. Prieto Conaway1, Shousong Cao2, Farukh Durrani2, Youcef Rustum2, Ping Wang3, Khin Marlar3, Latif Kazim3; 1Thermo Fisher Scientific, San Jose, CA, USA; 2Roswell Park Cancer Institute, Dept. of Cancer Biology, Buffalo, NY, USA; 3Roswell Park Cancer Institute, Dept. of Cell Stress Biology, Buffalo, NY, USA


 

 
 

  App. Note 404: Mapping O-GlcNAc and Phosphorylation Sites in C-MYC and CTD Peptides by Electron Transfer Dissociation Mass Spectrometry
 
 
Author(s):  Terry Zhang1, Tonya P. Second1, Rosa Viner1, T. Lakshmanan2 and Gerald W. Hart2; 1Thermo Fisher Scientific, 2Johns Hopkins University
 
 

App. Note 395: The Use of FAIMS to Separate Loperamide from PEG Prior to MS Analysis Using an LTQ XL   App. Note 395: The Use of FAIMS to Separate Loperamide from PEG Prior to MS Analysis Using an LTQ XL
 
 
Author(s): Julie Horner and Julian Phillips, Thermo Fisher Scientific, San Jose, CA
 
 

LTQ

  App. Note 357: Site-Specific Identification of 3-Nitrotyrosine and Nitrosocysteine Residues in Peptides Using MALDI Mass Spectrometry.
 
 
Author(s): Victor Sharov and Christian Schöneich; University of Kansas School of Pharmacy, Lawrence, KS, USA; Zhiqi Hao, Rosa Viner, Roger Biringer and Andreas Hühmer; Thermo Fisher Scientific, San Jose, CA, USA
 
 

  App. Note 350: Rapid Quantitative and Confirmational Screening for Drugs in Race Horse Urine by ESI-LC/MS/MS and MS/MS/MS.
 
 
Author(s): Patrick Russell,1 Paul Steinberg,2 Mary L. Blackburn,2 Diane Cho,2 Robert Heather2 (1University of Florida, Racing Laboratory, Gainesville, Florida; 2Thermo Fisher Scientific, San Jose, California)
 
 

  App. Note 345: Proteomics in ADME Tox Studies: High-Throughput Identification and ESI Linear Ion Trap Mass Spectrometry with 2D-DIGE. 
 
 
Author(s): Ola Rönn1, Johan Öhman1, Daniel Haid1, Helena Nordvarg1, Lena Hörnsten1, John Flensburg1, Erik Forsberg1, David Fenyö1,Hélèn Bergling1, Gary Woffendin2, and Michaela Scigelova2 (1GE Healthcare, Uppsala, Sweden; 2Thermo Fisher Scientific, Hemel Hempstead, UK)
 
 

 
  App. Note 343: Identification and Differential Expression Analysis of Putative and Known Plasma Biomarkers for Human Hypertrophic Cardiomyopathy.
 
 
 Author(s): Tori Richmond1, Manor Askenazi1, Leo Bonilla1, Robert E. Gerszten2, Jennifer Sutton1, Emerson Liu2, David Sarracino3 (1Biomarker Research Initiatives in Mass Spectrometry (BRIMS) Center, Thermo Fisher Scientific, Boston, MA; 2Cardiology Division and Center for Immunology & Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, MA; 3Harvard-Partners Center for Genetics and Genomics, Cambridge, MA)
 
 

 
  App. Note 338: Identification of Glycosylated Peptides from Data Dependent Neutral Loss Scans Using a Linear Ion Trap Mass Spectrometer.
 
 
Author(s): Gargi Choudhary, Jae Schwartz, and Diane Cho, Thermo Fisher Scientific, San Jose, CA Edited by: Wendy Schaeffer, Thermo Fisher Scientific, San Jose, CA
 
 

 
  App. Note 335: Characterization of Protein Glycosylation Using ESI ChipTM Static Nanospray Ion Trap MSn Mass Spectrometry
 
 
Author(s): Dirk Chelius1 and Sheng Zhang2; (1Thermo Fisher Scientific, San Jose, CA; 2Advion BioSciences, Inc., Ithaca, NY)
 
 

 
  App. Note 334: Determination of Choline and Its Metabolites Using a LTQ Linear Ion Trap Mass Spectrometer. 
 
 
Author(s): Gargi Choudhary, Bradley Hart, and Diane Cho, Thermo Fisher Scientific, San Jose, California; Marie Caudill, Human Nutrition and Food Sciences, Cal Poly, Pomona, California
 
 

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LXQ

App. Note 449: A Complete Toxicology Screening Procedure for Drugs and Toxic Compounds in Urine and Plasma Using LC-MS/MS   App. Note 449: A Complete Toxicology Screening Procedure for Drugs and Toxic Compounds in Urine and Plasma Using LC-MS/MS
 
 

Author(s): Marta Kozak, Taha Rezai, Thermo Fisher Scientific, San Jose, CA

 
 

  App. Note 369: A High Throughput Approach for Metabolite Profiling and Characterization Using the LXQ Linear Ion Trap Mass Spectrometer
 
 
Author(s): Min He, Alicia Du, Gargi Choudhary, Karen Salomon and Diane Cho; Thermo Fisher Scientific, San Jose, CA, USA
 
 

  App. Note 366: Analysis of Multiple Illicit Drugs, Methadone, and their Metabolites in Oral Fluid Using a Linear Ion Trap Mass Spectrometer
 
 
Author(s):  Min He, Gargi Choudhary, Diane Cho, Karen Salomon and Julian Phillips, Thermo Fisher Scientific, San Jose, CA, USA
 
 

  App. Note 363: Analysis of a Complex Sample of Bacterial Whole Cell Lysate from Haemophilus ducreyi Using the LXQ
 
 
Author(s): Kai Scheffler, Ph. D., Thermo Scientific GmbH, Dreieich, Germany
 
 

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