| In pharmaceutical analysis, chemical properties, efficacy, and purity are
generally well defined, but physical properties such as particle size are often
overlooked. Particle size can greatly affect flowability and compressibility of
the bulk raw material as well as dissolution, reaction rate, and tablet
integrity. Confirming the particle size of raw materials ensures that the
manufacturing process can be optimized to efficiently produce high-quality
finished products.
The primary method for determining particle size in fine powders requires
samples to be collected and passed through a jet sieve. Gravimetric analysis is
then used to determine the percentage of sample at any given mesh size. This
requires samples to be taken to a QC lab for analysis, resulting in loss of time
and efficiency. A more optimal method of analysis would provide instantaneous
results accurately without the need for a highly skilled operator. The Thermo
Scientific Antaris™ Fourier transform near-infrared (FT-NIR) analyzer is an
effective solution to determining particle size rapidly and accurately.
>>Complete list of FT-NIR Applications
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