| Conclusion
TurboFlow technology is a powerful technique for the direct analysis of drugs in biological fluids without the need for an extensive number of sample preparation steps. In this study, the use of an Aria TLX-1 LC system in front of a TSQ Quantum Ultra allows for low levels of detection (6.25 ng/mL for C-Dopa; 25 ng/mL for L-Dopa and 3-OMD) of each of these neurotransmitter compounds in human whole blood extract and yields results in less than 10 minutes per sample. With the Aria TLX-4 multiplexed system, the results will be available about every 2.5 minutes, or 24 per hour with the use of only one mass spectrometer. The low variability of the results demonstrates the reliability
of the method.
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