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  App.Note 436: Bioanalytical Assay for Neurotransmitters in Whole Blood by LC-MS/MS
 The goal of this application note is to develop a quantitative, fast, automated LC-MS/MS method for analysis of neurotransmitters in human whole blood.
 

Conclusion
TurboFlow technology is a powerful technique for the direct analysis of drugs in biological fluids without the need for an extensive number of sample preparation steps. In this study, the use of an  Aria TLX-1 LC system in front of a TSQ Quantum Ultra allows for low levels of detection (6.25 ng/mL  for C-Dopa; 25 ng/mL for L-Dopa and 3-OMD) of each of these neurotransmitter compounds in human whole blood extract and yields results in less than 10 minutes per sample. With the Aria TLX-4  multiplexed system, the results will be available about every 2.5 minutes, or 24 per hour with the  use of only one mass spectrometer. The low variability of the results demonstrates the reliability
of the method.

To read/download the complete pdf of this note, please use the link on the left side of this page.

   Products used for this Application
  PRODUCT #   Product Name   Image  
 IQLAAEGAAXFAGBMANC  Série TSQ Quantum      Choisir