Conclusions
Fourteen illicit drugs and metabolites are baseline separated in twelve minutes by employing UHPLC/MS with a ternary solvent gradient. Various selectivities are achieved by different column  surface chemistry, acidic solvent modifier and eluent system. These results are useful for method  developments of drug identification and quantitation. Detection by single quadrupole MS at the ppb  (ng/mL) level is more than sufficient to identify and quantify illicit drugs in real samples.

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