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  App. Note 448: LC-FAIMS-MS Validated Quantitation Method for a Peptide in Rat Serum
 The goal of this application note is to validate an LC-FAIMS-MS bioanalytical method for a peptide in rat serum according to FDA guidelines.
 

Conclusions:
A peptide quantitation assay was validated using FAIMS. Endogenous interferences which prevented validation in a traditional LC-MS assay, were successfully removed, resulting in an 18-fold increase in signal-to-noise ratio. The confirmation of LLOQ experiment was acceptable because FAIMS removed the interferences.

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   Products used for this Application
  Product #   Product Name   Image  
 IQLAAEGAAXFAGBMANC  TSQ Series Triple Stage Quadrupole Mass Spectrometers      Select
 IQLAAEGABBFACEMAFO  FAIMS Interface      Select