| The FT-Raman technique has many benefits in the analytical laboratory, including speed, easy sample preparation and spectral information that is interpreted in the same way as FT-IR spectra. Functional groups such as carbon double bonds produce strong FT-Raman vibrations, whereas functional groups with strong dipoles, such as water, are often weak in FT-Raman spectra. Therefore, aqueous solutions or samples in glass bottles can be measured directly. In addition, the active ingredients present in pharmaceutical tablets often show a very strong FT-Raman spectra while their excipients have much weaker vibrations.
FT-Raman allows most samples to be analyzed in their original form, which is a major advantage when the sample structure is subject to change with heat or pressure. Combined with the fact that samples can be measured directly in the sample bottle or packaging, the minimal sample preparation makes FT-Raman spectroscopy an ideal technique for QA/QC analysis methods. |
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