Unfortunately, estrone, a major component of most hormone therapies, and the metabolic product of both orally prescribed estrone and estradiol, has been implicated in cancers induced by hormone medicated therapies.

Estrogen levels in the body can be determined in a variety of ways. It is excreted in both the urine and feces, and is found in the blood stream of all adults. All three of these, urine, feces and blood, are complex matrices that can interfere with the hormone signal in chemical analysis.  Because of this, an analysis with a large amount of selectivity is required. NCI combined with MS/MS can give the high amount of selectivity needed in these biological matrices.

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