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  App. Note 355: Utility of H-SRM to Reduce Matrix Interference in Food Residue Analysis of Pesticides by LC/MS/MS Using the TSQ Quantum Discovery
 This application note llustrates the effectiveness of Highly-Selective Reaction Monitoring (H-SRM) for reducing background interference and improving s/n.
 And also, to develop a multi-residue LC/MS/MS screening method to detect 35 pesticides, and to exhibit the absence of “cross-talk” between co-eluting components.

An H-SRM LC/MS/MS method to monitor 35 pesticide residues was developed using the TSQ Quantum Discovery. All 35 pesticide residues were quantitated in 18 minutes. Using H-SRM, interferences from the sample matrix background were substantially reduced, leading to improved LOQs. Similarly, no cross-talk issues were detected for any of the tested analytes.

Compared with traditional single pesticide analysis methods, the sample preparation procedures are usually simplified in multi-pesticide analysis methods. This means more interference from the sample matrix may be present making H-SRM the technique of choice for improving detection limits.

To read/download a PDF of the complete application note, please use the link on the left of this page.

   Products used for this Application
  PRODUCT #   Product Name   Image  
 IQLAAEGAAXFAGBMANC  TSQ Series Triple Stage Quadrupole Mass Spectrometers      Seleccionar