The method shows excellent linearity (0.05 to 8.0 µg/kg), accuracy (90-106% recovery) and reproducibility (4-11% RSD), far exceeding the EU’s requirement of MRPL of 2 µg/kg of MG+LMG. The method has been implemented at the JSCIQ lab for routine monitoring of <0.5 µg/kg (MG+LMG) in roasted eel and other fish products (with variations of sample preparation procedures).

Highly selective reaction monitoring (H-SRM) has been shown to reduce the chemical noise effectively in the complicated sample matrix, which should be useful to further improve the method sensitivity and specificity (i.e., to eliminate both false positive and false negative) in support of enforcement of a “zero tolerance” policy toward the use of MG and LMG for aquaculture.

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