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  App. note 400: Chemical Background Removal in the Determination of Linoleic Acid Using LC-FAIMS-MS
 The goal of this note is to show the improvement in the lower level of quantitation (LLOQ) by removing chemical background in the analysis of linoleic acid in cancer cell extracts by using FAIMS technology.
 

The LLOQ in analysis of linoleic acid in cancer cell extracts was improved by removing chemical background and isobaric interferences using FAIMS. The signal-tonoise ratio was increased 10-fold, which translated into a 10× lowering of the LLOQ.

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