This technical note describes the application of the QuEChERS sample preparation procedure to analysis of pesticide residues in lettuce using gas chromatography and mass spectrometry (GC/MS) on the Thermo Scientific TRACE GC Ultra™  and Thermo Scientific DSQ™ II single quadrupole mass spectrometer . The DSQ II was operated in selected ion monitoring mode (SIM). A calibration curve was constructed in iceberg lettuce, and then the precision and accuracy of the analytical method were tested by preparing matrix spikes at 5 ng/g and 50 ng/g. An average limit of detection of 1 ng/g was achieved, and the average limit of quantitation was 3.6 ng/g, which readily meet published sensitivity requirements.

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