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  App.Note 431: Enhanced LC-MS/MS Selectivity for the Analysis of Human Urinary 8-isoprostane, using FAIMS
 The goal of this application note is to compare LC-MS/MS and LC-FAIMS-MS/MS for the detection of 8-isoprostane in human urine by using Selected Reaction Monitoring (SRM) and FAIMS.
 

Conclusion:
LC-FAIMS-MS/MS provided greater selectivity than conventional LC-MS/MS. The selectivity as measured by signal-to-noise ratio was improved by 21-fold by using FAIMS. The improved selectivity was a direct result of removing interferences and chemical background from the analysis of 8-isoprostane.

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   Products used for this Application
  Product #   Product Name   Image  
 IQLAAEGABBFACEMAFO  FAIMS Interface      Select