Conclusion:
A quick, automated online extraction, LC-MS/MS method has been developed here that is sensitive enough to detect 0.023 μg/kg (LOD) and quantify 0.047 μg/kg (LLOQ) of CAP in honey for screening purposes. This is significantly lower than the MRPL of 0.3 μg/kg (ppb) set by the EU. This method eliminates the need for time-consuming sample preparation procedures such as solid phase extraction, QuEChERS, and liquid-liquid extraction. Dilution with water to reduce sample viscosity is the only pretreatment required. The LC-MS/MS method run time is 5 minutes, and the sample throughput can be improved by multiplexing on an Aria TLX-4 system.

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