The results demonstrated in this application note show that the ultra-high sensitivityand high spectral quality offered by the LTQ mass spectrometer make it ideal for the analysis of enzymatically modified glycoproteins. The Data Dependent Neutral Loss experiment presented here enables determination of the position of elution, whereas the high sensitivity MS/MS and MS3 spectra generate information-rich data for structural elucidation of the various glycoforms of ribonuclease B.

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