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  Positive Ion Chemical Ionization and GC/MS for Confirmation and Quantitation of Benzoylecgonine in Oral Fluid
 A method has been developed to determine benzoylecgonine (BE), a major metabolite of cocaine, in oral fluids using gas chromatography and positive ion chemical ionization (PCI) with a single-stage quadrupole mass spectrometer.
  

A method for the GC/MS confirmation of benzoylecgonine in oral fluids was developed. GC/MS was used due to current widespread implementation of this methodology in many laboratories for routine confirmation of the presence of common drugs of abuse in urine samples. Though this analysis may be conducted using conventional electron impact (EI) ionization, the sensitivity and selectivity of the analytical method can be improved through the use of chemical ionization (CI).

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 SID-120266-1000  ToxLabâ„¢ 2.0 Intelligent Sequencing Software      Select