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LeadStream Poster Library


  • NEW! High Quality CYP 450 Inhibition results from LeadStream, were obtained in collaboration with Pfizer, St. Louis.  This poster provides assay methodology and compares results obtained by LeadStream with a semi-automated approach.
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  • NEW! High Quality Human and Rat microsomal stability results from LeadStream, were obtained in collaboration with Pfizer, St. Louis.  This poster provides assay methodology and compares results obtained by LeadStream with a semi-automated approch.
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  • NEW! Performance metrics for high throughput profiling, were obtain in collaboration with Pfizer St. Louis.  This poster provides results from a study of 600 analytes across three assays, in three laboratory days plus three days of unattended LC/MS analysis.
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  • LeadStream Orchestrator is a software layer that coordinates the ADME/Tox process to achieve continuous flow and end-to-end data tracking. This poster explains its architecture and relationship to other software packages within the LeadStream ADME/Tox solution.
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  • LeadStream Reformatter is a progressive sample distribution subsystem that functions within the LeadStream ADME/Tox solution to select compounds from a local store and prepare them in proper formats for specific assays.
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  • LeadStream WorkCell is a fully integrated and automated subsystem for conducting sample preparation and standard readout end-points. It has been shown to demonstrate reliable data for Metabolic Stability assays.
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  • QuickQuan is a new software layer that provides critical support for operation of LC/MS within a screening context. QuickQuan automatically tunes Mass Spectrometer conditions to optimize signal in SRM mode for each analyte, and provides workflow support for automated results processing.
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  • ADME_Quan is a software layer within the LeadStream environment that facilitates seamless communication between LeadStream Orchestrator and the software supporting the operation of the LeadStream LC/MS: QuickQuan and XCalibur. The net result is end to end data tracking that includes mass spectrometry.
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