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Liquid chromatography – tandem mass spectrometry is a highly selective technique for bioanalysis, but for challenging assays, LC-MS is often not selective enough. Issues such as high chemical background, co-eluting isobaric ions, and long analytical run times force researchers to redevelop and validate assays. This process is time consuming and costly, with no guarantee of success. FAIMS is a unique problem solving tool for LC-MS methods development enabling many of the aforementioned challenges to be solved quickly and cost effectively. For increased selectivity, the FAIMS device is installed in the atmospheric pressure region between the ion source and the mass spectrometer. In just a few minutes the system is ready to exploit three complementary dimensions of separation: LC, FAIMS, and MS. The simplicity of the hardware design, the ease of installation and use, and the speed in which challenges are solved make FAIMS a technique that should be used early in the LC-MS method development process. The increased selectivity will lead to accelerated method development and improved robustness in LC-MS analyses. |
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