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Rapid Method Acepromazine Using LC-MS/MS with Ion Trap MS

Introduction

Acepromazine is widely used as a sedative in horses as it serves as a tranquilizer which facilitates handling of these large mammals before transportation or surgical procedures. Acepromazine has been classified by the Association of Racing Commissioners International, Inc. as a Class 3 drug in horses. Abuse of the drug may result in 60 days-6 months of suspension and up to $1500 fine and loss of purse. Acepromazine has a slow elimination rate and stays in the body for an extended time. This can be problematic if the drug is administered before events since its calming effect can lead to enhanced performance by the horse

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   Rapid Method for Identification and Quantitation of Acepromazine and its Major Metabolite in Horse Serum using an Ion Trap Mass (46 Kb)