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PSB118 Data Dependent Constant Neutral Loss Scan Function for Identification of Biotransformations Using Thermo Scientific Ion Trap Mass Spectrometers
An application of Data Dependent™constant neutral loss (DDCNL) scanning to identify in vitro metabolites of glyburide is illustrated. This experiment was performed with a user-defined neutral loss of 125. By scanning the chromatogram in real time for a constant neutral loss of 125, the DDCNL scan function triggers an MS3 scan for a metabolite at m/z 510.

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