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LTQ XL and LTQ Product Support Bulletins
Below are links to PDF electronic documents for each of the Product Support Bulletins that apply to the LTQ. To load the PDF, select any of the links below. (a free copy of Acrobat Reader can be downloaded from www.adobe.com/reader)

PSB126 Merging CID and ETD Database Search Results to Increase Confidence in Protein ID

  

PSB126 Merging CID and ETD Database Search Results to Increase Confidence in Protein ID

Electron transfer dissociation (ETD) is an activation method that is complementary to CID. It not only favors multiply charged peptides, but also preserves labile post translational modifications (PTMs). Recent studies indicate that increased identification confidence is obtained using a combined CID and ETD approach for peptide/protein identification
 
 
 

 

PSB124 Pulsed Q Collision Induced Dissociation (PQD) on Linear Ion Trap Mass Spectrometers 
 

Recently, a new dissociation technique called Pulsed Q Collision Induced Dissociation (PQD), has been developed by Thermo Fisher Scientific and implemented exclusively for their linear ion trap mass spectrometers
 
 

PSB123

  

PSB123 Improved  Selectivity and Isolation Efficiency Using High Resolution Isolation in a Thermo Scientific LTQ XL™ Ion Trap Mass Spectrometer 
 

A new ion isolation technique which can achieve high resolution ion isolation (HRI) offers improved selectivity such as isobaric separation, as well as non-dissociative isolation of labile ions
 
 
PSB122  

PSB122 Using Multistage Activation in an Ion Trap Mass Spectrometer
 

Data Dependent™ Neutral Loss MS3 (DDNLMS3) analysis enables selective fragmentation
 
 

PSB121

  

PSB121 Enhanced Fragmentation of Small Molecules in a Thermo Scientific LTQ™ Linear Ion Trap Mass Spectrometer Using Stepped Normalized Collision Energy
 

The Stepped Normalized Collision Energy (SNCE) process applies several different Normalized Collision Energy “steps” to a sample during ion dissociation
 
 
 
PSB120  

PSB120 Advanced Data Dependent™ Analysis for Ion Trap Mass Spectrometers
 

Data Dependent acquisition using Ion Trap mass spectrometers allows automated real-time decisions for subsequent MSn analysis
 
 

PSB120

  

PSB119 Scan Speed vs Cycle Time on an Ion Trap Mass Spectrometer
 

 achieve maximum benefit in an LC/MSn experiment, the series of events starting from the process of filling the ion trap through detecting the ions must be optimized for a chromatographic timescale
 
 
PSB118   PSB118 Data Dependent Constant Neutral Loss Scan Function for Identification of Biotransformations Using Thermo Scientific Ion Trap Mass Spectrometers
 
 

An application of Data Dependent™ constant neutral loss (DDCNL) scanning to identify in vitro metabolites of glyburide is illustrated
 
 
 

 
PSB117   PSB117 Radial Ejection and Dual Detection on Thermo Scientific LTQ Series Linear Ion Trap Mass Spectrometers  
 
The LTQ™ series two dimensional (2D) linear ion trap mass spectrometer represent a major leap in ion trap technology from the traditional 3D quadrupole ion traps
 
 
 
PSB116   PSB116 Analysis of Post-Translation Modifications Using a Data Dependent™ Neutral Loss Scan Function 
 
 

Post-translational modifications, such as phosphorylation and glycosylation, are associated with regulation, location and function of proteins
 
 
 

 
PSB114   PSB114 Isotope Pattern Recognition Using Metabolite ID 2.0 Software
 

To demonstrate the capabilities of isotope pattern searching, in-vitro metabolism of diazepam was studied using LC/MS in conjunction with Metabolite ID 2.0 software
 
 
 
PSB104   PSB104 Normalized Collision Energy™ Technology
 

For the first time MSn spectra are now as reproducible as electron impact spectra. The combination of Normalized Collision Energy with WideBand Activation™ means that spectral libraries can be built, searched and exchanged
 
 
 
PSB102   PSB102 WideBand Activation™ Technology  
 

The resonance excitation process used for MSn in an ion trap device fragments only the selected ion