Dear
Subscriber,
In the current Issue of Critical Mass, we have a
section titled "We Value your feedback". This section has a few
questions, the answers to which would help us tailor Critical Mass
to better suit your needs. We would greatly appreciate it if you
could take some time to answer these questions. This survey should
take not more than 2 mins. to answer. Our intention is to further
evolve Critical Mass based on your input.
We thank you for your
time and interest.
Yours Sincerely,
Critical Mass Editorial
Team
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| Perspective: Mass
Spectrometry & Quantitative Bioanalyses |
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During the late
1980s, the market for mass spectrometers with the ability to
perform MS/MS was relatively small. GC/MS, which made up the
overwhelming number of mass spectrometers sold in the world,
already provided a spectrum. For most GC/MS analyses,
compounds break apart in the Electron Impact (EI) source,
which is standard with most GC/MS instruments. The
fragmentation spectrum produced a fingerprint that identified
the library-searchable compound. MS/MS, which fragments ions,
was of little or no use since the compounds always fragmented
on its own. Occasionally, Chemical Ionization (CI) was used
with GC/MS which yielded a single species (pseudomolecular
ion). This technique was often used to increase sensitivity
for quantitative analyses. Primarily, MS/MS was relegated to
research labs performing qualitative analyses. |
| Read Full
Article | |
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| Software
Update |
|
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- Get the
latest updates (SUR1 and SUR2) for Xcalibur 1.4 SR1. [Download]
-
Mass Frontier 4.0 Service Release 2.37 (released December 1,
2004): Go to www.highchem.com, click on
'Downloads' and follow the instructions.
- Your opinion
matters! Please take a moment to submit a request for some new
software functionality and be a winner in more ways than one!
[Submit
Request]
- If you have created an XDK application that
you would like to share with others, contact us at xcalibur@thermo.com. |
| |
| Proteomics
Applications |
|
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- Characterization of
protein glycosylation using chip-based infusion
nanoelectrospray linear ion trap tandem mass spectrometry. [Read
Paper]
- Peptide and protein sequence analysis by
electron transfer dissociation mass spectrometry. [Read
Paper]
- Improved peptide identification in proteomics
by two consecutive stages of mass spectrometric fragmentation.
[Read
Paper] |
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| Small Molecule
Applications |
|
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- Simultaneous analytical
method for the determination of TCH346 and its four
metabolites in human plasma by liquid chromatography/tandem
mass spectrometry. [Read
Paper]
- Quantification of cyclophosphamide and its
metabolites in urine using liquid chromatography/tandem mass
spectrometry. [Read
Paper]
- Distinguishing N-oxide and hydroxyl compounds:
impact of heated capillary/heated ion transfer tube in
inducing atmospheric pressure ionization source
decompositions. [Read
Paper] |
| | |
| Trap Talk: Screening
Drugs and their Metabolites |
|
Imipramine is
a tricyclic antidepressant drug that is not classifed as a
controlled substance by the Drug Enforcement Administration,
but is classified by the Association of Racing Commissioners
International Inc. as a class 2 drug in horses. Desipramine is
a major metabolite of imipramine. Extracts of horse urine were
screened for both analytes using on-line LC-PDA MS/MS.
This
application note presents a rapid method for quantifying
imipramine and desipramine in horse urine, illustrating the
advantages of MS/MS detection in terms of specificity,
sensitivity and unambiguous identification for the analysis of
drugs and their metabolites. |
 |
| Download Full
Article |
|
| MSeminar: Mass
Spectrometry Webinars |
 |
Featuring Webinars in Proteomics,
Drug Discovery, Bioanalysis, Environmental Applications &
more...
Coming Soon: A New Schedule of LIVE Web
Seminars at www.thermo.com/mseminar |
| View Recorded
Webinars |
|
|
| Through the
Customer's Eyes |
|
|
"Scientists involved in
the fight against cancer often need to gather information
about specific gene products that are thought to be required
for the progression or the disease or that might serve as
biomarkers for diagnosis. My laboratory purchased several mass
spectrometers from Thermo Electron over the past three years
which we use to identify the gene products for investigators
in the scientific community. Thermo Electron instruments have
provided great sensitivity and reliability over the years and
have allowed me to concentrate my own efforts on developing
technology for the study of tumor biology."
-- Steven
Gygi, Ph.D.
Assistant Professor of Cell Biology at Harvard
Medical School
Director, Taplin Biological Mass
Spectrometry Facility at Harvard Medical School
(personal views of
Dr. Gygi do not necessarily represent those of Harvard Medical
School) |
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