Dear
Subscriber,
Welcome to the first edition of Critical Mass.
Critical Mass is more than just an eNewsletter. It opens the
door to unlimited knowledge, providing additional information to
help you run your lab more efficiently and effectively. We hope this
monthly newsletter will keep you up-to-date with the latest
innovations in mass spectrometry that can lead you in new directions
and guide you through challenging times.
We will continue to
evolve Critical Mass based on your comments and feedback.
Please feel free to send any comments or suggestions to criticalmass@thermo.com. Here
is a message from the Director of Global Product Marketing for
Life Sciences Mass Spectrometry at Thermo.
Best
Regards,
Critical Mass Editorial Team
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| Celebrating
25 Years of Innovation in Ion Traps |
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Returning from the 1979 ASMS conference in Seattle,
George Stafford, John Syka and colleagues started their
research on mass-selective instability and fabricated the
first ion trap assembly at Finnigan Corp. in San Jose,
CA.
Download
the Current Generation of Ion Traps!! (148kb,
PDF)
Watch this space for
the upcoming eSeminar
Series!! |
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| Proteomics
Applications |
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Dramatic
Productivity Improvement for Protein Identification Using a
New Two-Dimensional IonTrap Mass Spectrometer [Download]
Radically
Improved Bottom-Up Protein Identification using a Finnigan LTQ
Ion Trap Mass Spectrometer [Download]
Identification
of Phosphorylation Sites Using Automated Chip-Based
Nanoelectrospray Using the LTQ [Download]
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| More
Proteomics Application Notes &
Posters |
| Software |
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Find Software downloads and other valuable
information at our support website. |
| ASMS
Success |
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| Small
Molecule Applications |
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Analysis of a
Verapamil Microsomal Incubation using Metabolite ID and Mass
Frontier [Download]
Bioanalytical
Method Intraday Validation for the Quantitation of Paroxetine
in Bovine Plasma using the Finnigan TSQ Quantum Mass
Spectrometer [Download]
Increased
Analyte Sensitivity through the Utility of Enhanced
Mass-Resolution on the Finnigan TSQ Quantum Discovery [Download]
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| More
Small Molecule Applications |
| Accurate Mass |
| Fully
automated high throughput accurate mass determination using
FT-ICR MS [Download] |
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| Quantitation?
Think Quantum |
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Find out why the Quantum is ideal for Quantitation
in a six part series featured in this column. In the next
Issue: Sensitivity and the
Quantum. |
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| Trap Talk:
Normalized Collision Energy(TM) |
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The
collision energy needed to achieve optimum fragmentation
efficiency has been shown to follow a linear correlation with
m/z. Thus, automatically varying the actual collision energy
based on the precursor m/z value is the key to obtaining a
reliable pattern of product ions.
Normalized Collision
energy becomes significant in protein digests where the
peptides generated lie across a range of m/z values. It
ensures that high quality MSn data are collected
automatically, whatever the mass of the analyte. In addition,
since the normalized collision energy is calibrated on all of
Thermo's Finnigan mass spectrometers, minimal system to system
variation is ensured resulting in reproducible spectra on all
systems.
For the first time LC/MS-MS spectra are
reproducible across instruments and laboratories. The figure
shows data from two different instruments in two different
continents to be almost ide! ntical. The combinations of
Normalized Collision Energy with WideBand Activation(TM) means
that spectral libraries can be built, searched and
exchanged...more.
In the next issue: WideBand
Activation(TM).
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| Proteomics News |
Attend
our European Proteomics Courses.
Watch
the new vMALDI Video.
Download
Proteomics Pioneers Vol1. including interviews with
experts: Cheryl Arrowsmith, Al Burlingame, Graham Cooks,
Koichi Tanaka, Phil Andrews, Richard Johnson, David Goodlett,
Emanuel Petricoin, Dolores Cahill, Ian Humphery-Smith, Stephen
Burley, Dennis Hochstrasser, Leigh Anderson
Be sure to
visit Thermo at the 15th
Conference of Methods in Protein Structure
Analysis
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| Scientist
Profile |
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| Relay for
Life |
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...is pleased to participate in the Relay for Life
with the American Cancer Society because the diagnostic
discovery and treatment of cancers and other life-threatening
diseases is a key area that our mass spectrometers are being
applied...more |
| Through the
Customer's Eyes |
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"With the
Quantums, you just turn them on and they run forever."
-- Bill Cusick, Director, California Department of
Food and Agriculture, January 2004
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