Life Sciences Mass Spectrometry eNewsletter
Critical Mass, Issue 7
January 2005
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 Proteomics(n) at ABRF 2005: Visit Thermo at Booth 801  
Thermo Electron is a proud sponsor of the 2005 ABRF Conference held February 5-8 in Savannah GA. At this important meeting, Thermo will showcase exciting new instruments, software, and applications that take the rapidly developing science of protein analysis and proteomics to a whole new level. Visit us at the Thermo booth to learn about Proteomics(n) solutions for High-Throughput Protein ID, Ultra-Sensitive PTM Characterization, Top Down Protein Analysis and Biomarker Discovery. These applications will be shown in practical detail in a series of technical workshops and posters. If you cannot attend the ABRF Conference, but would like more information on Proteomics(n) or Thermo products or applications, please visit thermo.com/proteomics.
Download Thermo ABRF Conference Guide 

 Thermo's Technical Workshops: LIVE from ABRF  
Not attending ABRF? Attend Thermo's Technical Workshops LIVE at your desk.

- Massive Parallel Searching of MS/MS Data Using a Novel SEQUEST Accelerator: Dr. Steve Gygi, Assistant Professor, Dept. of Cell Biology, Harvard Medical School; 12 Noon EST Monday Feb 7th 2005 [Register/Attend]
- Top-Down Proteomics - A Definitive New Approach to Intact Protein Analysis: Dr. Andrew Forbes, Center for Top-Down Proteomics, University of Illinois at Urbana-Champaign; 12 Noon EST Tuesday Feb 8th 2005 [Register/Attend]
* Please register only once. You may use the same login and password for all Thermo Mass Spectrometry Web Seminars. Participation in the exhibitor workshop program at the ABRF meeting does not constitute an endorsement by ABRF of the claims, products, or services offered.
 

 Featured Software: ProMass(TM) Deconvolution 2.0  
ProMass Deconvolution 2.0 is an automated biomolecule deconvolution and reporting software package that is used to process ESI/LC/MS data or single ESI mass spectra acquired with the Xcalibur data system. ProMass can be set up to run automatically from Xcalibur with the data presented in easy-viewing web browser format. ProMass is ideal for the analysis of intact proteins and oligonucleotides and is optimized for high-throughput applications. Give this software a try.
* ProMass is a Trademark of Novatia, LLC.
Download your demo copy of ProMass Deconvolution 2.0 today. 

 Proteomics Applications  
- Shotgun sequencing of the human cerebrospinal fluid proteome using 2D LC/MS with the Finnigan ProteomeX LTQ [Download]
- High-throughput analysis in proteomics: Parallel mass detection using the Finnigan LTQ FT [Download]
 

 News: Video Clips, Downloads & more...  
- Thermo's 2005 laminated Wall Calendar [Order your FREE copy Now]
- Center for Proteomics Excellence 2.0 CD-ROM [Order your FREE copy Now]
- HPLC Analysis of Biomolecules Guide [Order your FREE copy Now]
- Introduction to the most sensitive and advanced Triple Quad [Video Clip]
- Rapid Accurate Protein Identification [Video Clip]
 

 Small Molecule Applications  
- High-sensitivity quantitation of cabergoline and pergolide using a triple-quadrupole mass spectrometer with enhanced mass-resolution capabilities [Read Paper]
- Enhanced resolution triple-quadrupole mass spectrometry for fast quantitative bioanalysis using liquid chromatography/ tandem mass spectrometry: investigations of parameters that affect ruggedness [Read Paper]
 

 Quote Corner  
Thermo is pleased to participate in the Relay for Life with the American Cancer Society because our mass spectrometers play a major role in the diagnosis and treatment of cancers and other life-threatening diseases. Prominent research institutes plus major pharmaceutical and biotech companies around the world use Thermo mass spectrometers to advance the science of medical discovery.
"Currently, mass spectrometers are the instruments of choice for discovering biomarkers that are then used for early diagnosis of cancer. The same instruments are also being used in my laboratory to discover molecules that stimulate the immune system and that can be used as either vaccines or therapeutics against cancer."
-- Donald F. Hunt, Ph. D.
Professor of Chemistry & Pathology
University of Virginia
 

 Thermo at US HUPO  
The first US HUPO Symposium will be held March 13-16, 2005 at the prestigious Crystal Hyatt Hotel, one of Washington DC's finest facilities. The mission of the US HUPO 2005 Symposium is to foster the discussion and dissemination of knowledge pertaining to the proteomes of man and model organisms. The focus of the symposium is broad, ranging from proteome mapping and application of proteomics methods in problem solving to biomarker discovery and molecular medicine. Topics discussed at the symposium will stretch from the development of new analytical tools and methods that enhance throughput, structural characterization, and cellular imaging to the study of functional proteomics, protein:protein interactions, post-translational modifications, recognition of stimulus associated changes in the proteomes, and bioinformatics. A commercial exhibition will be included where the latest advances in proteomics instrumentation, supplies, and services will be presented. For more information visit http://www.purdue.edu/dp/ushupo/.
 

 Trap Talk: Accurate Mass Measurements  
High resolution, accurate mass spectral analysis is an essential tool for structural elucidation in the fields of chemistry and biochemistry. Use of accurate mass information facilitates the identification of known compounds and determination of elemental composition for unknowns. High resolution analysis allows isobaric compounds to be separated from one another or from chemical noise. For the identification of unknowns, it is desirable to perform the highest mass accuracy measurements possible in order to eliminate false positives.
Download Full Article 

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