| View archived issues on the web at www.thermo.com/criticalmass |
| Tip
of the month: Monitor Spray Current |
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ESI relies on a
stable spray. When working with high concentrations of buffer
in mobile phase, it is common to observe a fluctuation in the
spray current. Monitor the current through the read back views
and if there is fluctuation or an unusually high current
value, try lowering the buffer concentration and adjust the
sprayer positioning. |
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| LIVE Webinar:
Metabolism Studies 2 |
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Title: Simultaneous
Metabolite Identification and Metabolic Stability on the
Finnigan™ LTQ™ Linear Ion
Trap
Agenda: A high-throughput strategy to
accelerate the lead optimization phase in the drug development
cycle will be presented. This strategy involves the
simultaneous determination of the nature and extent of
metabolism by performing metabolite identification and
metabolic stability measurements in a single analytical run.
The combination of ultra-fast cycle time and high spectral
quality on the LTQ are key to achieving these
results.
Speaker: Gargi Choudhary, Ph.D., Senior
Applications Scientist, Thermo Electron Corporation |
| Register
Now |
| ASMS 2005 Events from
Thermo |
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Thermo has several events
planned for ASMS 2005, including:
User Meeting: This
application-focused event will take place Sunday morning June
5th beginning from 7:30PM to 12:00PM.
Annual Customer
Appreciation Event: This event will take place immediately
after the morning User Meeting.
Lunchtime Sessions:
These sessions will take place Monday through Wednesday June
6th-8th from 12:30PM to 1:20PM
Hospitality
Suite: The suite will be open Monday through Wednesday
June 6th - 8th from 6:30PM - 9:30PM. |
| More
Information |
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| Recorded: Metabolism
Studies 1 |
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Title:
High-throughput Metabolite Identification on the Finnigan LTQ
Linear Ion Trap
Agenda: High-throughput strategies
for the identification of metabolites utilizing the ultra-fast
cycle time and sensitivity of the Finnigan LTQ will be
presented. The...
Speaker: Scott Peterman,
Ph.D. |
| View Recording
Now |
| Recorded:
QuickQuan |
|
Title: QuickQuan -
Enabling High-throughput LC/MS for Discovery
Quantification
Agenda: To eliminate drugs
with unsuitable properties as early as possible in the drug
development process, pharmacokinetic (PK) screening is getting
more and more...
Speaker: Louis Maljers |
| View Recording
Now |
| Biomarker Center
Grand Opening |
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| This year in Boston, March
17th marked another exciting event - the Grand Opening of
Thermo Electron's BRIMS (Biomarker Research Initiatives in
Mass Spectrometry) Center in collaboration with the
Massachusetts General Hospital (MGH), followed by a seminar
and cocktail reception at the Hotel@MIT. The BRIMS Center was
established to develop, validate and share turn-key
mass-spec-based workflows enabling high-throughput biomarker
discovery research using a disease model that is arguably the
most critical human health issue of our era - ... |
| Read
Article |
|
| Quantum Waves: H-SRM
for the assay of a CNS depressant |
|
Midazolam is a
CNS depressant that is commonly used as a sedative prior to
surgical or other medical procedures. It is a controlled
substance which, when abused, can cause serious side effects
including amnesia, respiratory depression or even
death.
The TSQ™ Quantum
line of triple quadrupole mass spectrometers offers the unique
capability of highly-selective reaction monitoring (H-SRM).
H-SRM is... |
 |
| Download
Application Note (PDF 144
KB) |
| Heavy
petroleum crude oil analysis using the Finnigan LTQ FT™ |
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As world-wide
petroleum reserves evolve towards heavier crude oils,
effective processing of heavy petroleum becomes increasingly
important. Heavy crude oil is a complex mixture of
hydrocarbons, containing multiple aromatic rings including
heterocycles of N, S and O and crude acids in its polar
fraction. Variation in the oil composition directly affects
the downstream processing. The chemical makeup of low and mid
boilers has been extensively studied by such techniques as
GC/MS and LC/MS; however, the data on heavy fractions is
scarce, primarily due to analytical difficulties presented by
their complex... |
| Download Full
Application Note (PDF 371
KB) |
| Proteomics Seminar
Tour (North America only) |
|
The tour is a
FREE one-day seminar with customer presenters sharing their
experiences and highlighting the latest applications and
techniques for a range of topics relating to Proteomics and
Biomarker Discovery highlighting:
- Top-Down Proteomics
Made Simple
- Label-Free Quantitative Proteomics for
Biomarker Discovery
- High-Throughput Phosphopeptide
Identification using MALDI-MS/MS
- Protein Fractionation
and Purification to Probe the Low Molecular Weight
Proteome
- Practical Use of Stable Isotope Labeling for
Investigating Protein Expression
- And more . . . |
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| More
Information |
| Trap
Talk: Radial Ejection and Dual Detection |
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The Finnigan LTQ
two dimensional (2D) linear ion trap mass spectrometer, with
its unique features, represents a major leap in ion trap
technology from the traditional 3D quadrupole ion traps which
have been a reliable tool for structural identification in
complex matrices. The 2D linear ion trap in the LTQ is
comprised of four parallel hyperbolic shaped rods, segmented
into three sections. Ions are trapped radially in a radio
frequency (RF) electric field and axially in a static electric
field using DC voltages. Application of appropriate voltages
to all three segments generates a homogenous field
throughout... |
| Download Full
Article (PDF 391
KB) |
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