| Breakthrough Technology
Launched at ASMS |
Visit: thermo.com | |
| Thermo unveiled several new products at the
American Society for Mass Spectrometry (ASMS) Conference in San
Antonio, Texas earlier this month. Most significant was the launch
of the LTQ Orbitrap™, a hybrid mass spectrometer that, compared to
Time-of-Flight (TOF) technology, offers superior mass resolution and
accuracy, detection power and dynamic range. The LTQ Orbitrap's
patented technology represents possibly the most significant
breakthrough in mass spectrometry since the introduction of the ion
trap mass spectrometer over 20 years ago. |
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| Introducing the LTQ
Orbitrap |
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| Combining patented
Orbitrap technology with the highly successful Finnigan™ LTQ™ linear ion trap, Thermo's LTQ
Orbitrap enables faster, more sensitive and more reliable
detection and identification of compounds in complex mixtures.
Its outstanding mass accuracy, mass resolution and reliable
high sensitivity MSn performance make it a clear alternative
to hybrid Time-of-Flight systems. |
| Download Brochure
(PDF 415kB) |
| Discovery™1.2 for Xcalibur™ 1.4SR1 |
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Discovery software
provides a completely automated solution for high throughput
mass screening programs. Specifically developed to fulfill the
needs of combinatorial chemists, Discovery is also suited to
other applications requiring:
- High-throughput
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Product confirmation
- Purity assessment via various
detectors
- Microtitre plate sampling |
| More
Information |
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| MSeminar: LTQ
Orbitrap Webinar |
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Speaker: Helmut
Muenster, Ph.D.
Agenda: The webinar will introduce
the LTQ Orbitrap technique followed by an explanation of the
geometry of the hybrid instrument. This will be followed by a
discussion of specifications and performance highlights. The
webinar will conclude with some examples for drug-discovery
and bottom-up proteomics.
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| Register
Now |
| Open Access™1.3 for Xcalibur
1.4SR1 |
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| Open Access allows
chemists to routinely achieve quick, consistent, qualitative,
LC/GC-MS and LC-MS/MS data analysis without the need for mass
spectrometry expertise. Users simply walk up to the
instrument, log in their sample information, select a
predefined method, drop their sample into the autosampler, and
return to their lab to await their results via email - minimal
instrument expertise and minimal operator interface is all
that is required. |
| More
Information |
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| Tip
of the Month: Spray Voltage with Metal
Needle |
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When operating in
ESI mode with the metal needle, set the Spray Voltage 500 V
lower than when using the fused silica inlet tubing. Pay close
attention in negative ion mode not to create a corona
discharge (visible by a blue glow at the ESI needle tip).
Lower the Spray Voltage as necessary to prevent the corona
discharge. |
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| Proteomics
Application: Proteomics in ADME/Tox Studies |
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| It is
estimated that about 50% of drugs in development fail during
clinical trials because of deficiencies in their ADME/Tox
properties (absorption, distribution, metabolism, elimination
and toxicity). The cost of these failures so late in the drug
development process is naturally very high. Improved means of
gathering ADME/Tox information earlier in the drug development
process should thus benefit pharmaceutical manufacturers. To
understand the processes related to the metabolism and
potential toxicity of a candidate drug we chose to combine the
method of 2-D Difference Gel Electrophoresis (DIGE) to
highlight proteins which are significantly up- or
down-regulated after the administration of the drug, with
analytical mass spectrometry to unambiguously identify such
proteins. |
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| Download Full
Article (PDF 244kB) |
| Quantum Waves:
Measurement of Metabolic Stability and ID of
Metabolites |
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In vitro
pharmacokinetic data, such as metabolic stability and the
identification of metabolites have become important tools in
early drug discovery. In Johnson & Johnson Pharmaceutical
Research and Development, rat hepatocytes are applied in early
drug discovery for studying both compound metabolic stability
and metabolite formation. The analytical procedure utilizes
LC-MS/MS for the study of compound turnover (in vitro
half-life and subsequent calculation of physiological relevant
hepatic clearance data) and the identification of Phase I and
II metabolites. This report demonstrates the role of the
Finnigan™ TSQ™ Quantum Discovery in carrying
out in vitro studies of compound metabolic stability and
identification of Phase I and II metabolites. |
| Download Full
Article (PDF 285kB) |
| Support Plans for
Scientific Instruments |
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We offer a
range of support plans to help you achieve the greatest value
from your technology investment by maintaining top performance
from your instruments, maximizing uptime and productivity, and
eliminating the uncontrollable cost of unplanned maintenance
and repairs. A support plan helps you:
- Improve
productivity and quality
- Increase production uptime
- Extend instrument lifetime... |
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| More
Information |
| Trap
Talk: Data Dependent™
Constant Neutral Loss Scan |
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Determination of
the metabolic fate of drugs is an essential and important part
of the drug development process. In Vitro biotransformation
studies are commonly performed in the early drug discovery to
determine metabolic pathways and to generate Phase I and Phase
II metabolites for further characterization. The wide variety
of potential metabolites and resulting complex mixtures make
their identification a challenging and labor-intensive task.
The Data Dependent constant neutral loss (DDCNL) scan function
that is available on all Finnigan Ion Trap Mass spectrometers
significantly expedites identification of these
metabolites. |
| Download Full
Article (PDF
83kB) |
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